摘要
目的:优化复方黄芪乳膏的处方并对其流变学性质进行评价。方法:以复方黄芪乳膏的外观性状、涂展性和稳定性作为评价指标,采用层次分析法(AHP),基于指标相关性的指标权重确定方法(CRITIC),AHP-CRITIC混合加权法确定各评价指标的权重系数,结合D-最优混料设计优化复方黄芪乳膏的处方,并对其流变学性质进行评价。结果:按AHP-CRITIC混合加权法得到外观性状、涂展性和稳定性的权重系数分别为0.185,0.282和0.532,D-最优混料设计得到复方黄芪乳膏最优基质处方为液体石蜡3.70 g,白凡士林2.00 g,硬脂酸2.00 g,十二烷基硫酸钠5.90 g,甘油6.00 g,提取液20.40 g。复方黄芪乳膏流变学参数为非牛顿指数<1,储能模量>损耗模量。结论:优选的基质处方稳定可行。复方黄芪乳膏外观良好,是剪切变稀型非牛顿流体,黏度和延展性符合工业生产及临床应用的需要。
Objective:To optimize the matrix prescription of Fufang Huangqi cream and evaluate its rheological properties.Method:With appearance,spreadability and stability as evaluation indexes,the weighting coefficient of each evaluation index was determined by analytic hierarchy process(AHP),criteria importance through intercriteria correlation method(CRITIC)and AHP-CRITIC mixed weighting method.The formulation of Fufang Huangqi cream was optimized by D-optimal mixture design and its rheological properties were evaluated.Result:The weight coefficients of appearance,spreadability and stability according to AHP-CRITIC mixed weighting method were 0.185,0.282 and 0.532,respectively.According to D-optimal mixture design based on AHP-CRITIC analysis,the optimized formulation of Fufang Huangqi cream was liquid paraffin of 3.70 g,vaseline of 2.00 g,stearic acid of 2.00 g,sodium dodecyl sulfate of 5.90 g,glycerin of 6.00 g and extract of 20.40 g.The rheological parameters of Fufang Huangqi cream was non-newtonian index<1,storage modulus>loss modulus.Conclusion:The preferred matrix formulation is stable and feasible.Fufang Huangqi cream has good appearance and is a shear thinning non-newtonian fluid.Its viscosity and ductility meet the needs of industrial production and clinical application.
作者
王永洁
孙铭忆
邓莉莉
赵颖
刘鑫
刘欣妍
刘葭
吴清
李园
WANG Yong-jie;SUN Ming-yi;DENG Li-li;ZHAO Ying;LIU Xin;LIU Xin-yan;LIU Jia;WU Qing;LI Yuan(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China;China-Japan Friendship Hospital,Beijing 100029,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第3期110-116,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
北京市科委“十病十药”研发项目(Z161100001816015)。
关键词
复方黄芪乳膏
D-最优混料设计
层次分析法
基于指标相关性的指标权重确定方法
流变学
涂展性
稳定性
Fufang Huangqi cream
D-optimal mixture design
analytic hierarchy process
criteria importance through intercriteria correlation method
rheology
spreadability
stability
