摘要
表观遗传学是指不涉及DNA序列改变,但在基因表达过程中产生的可遗传改变的遗传学分支学科.表观遗传学调控机制涉及DNA甲基化、microRNA和组蛋白修饰等方面.法洛四联症(tetralogy of Fallot,TOF)是一种常见的先天性心脏病,其特征是室间隔缺损、肺动脉狭窄、主动脉骑跨和右心室肥厚.大量研究表明,表观遗传学在心脏的发育过程中发挥着重要的作用,从表观遗传学的角度来研究法洛四联症的发病原因,将是未来重要的研究内容,具有重要的临床意义.
Epigenetics refers to the heritable changes of gene expression without altering DNA sequence.Epigentic mechanism involves DNA methylation,microRNA,histone modification and so on.Tetralogy of Fallot(TOF)is a common congenital heart disease characterized by ventricular septal defect,pulmonary stenosis,aortic straddling and right ventricular hypertrophy.Many experimental investigations indicate that epigentics plays an important role in the development of the heart.It will be an important research field in the future showing important clinical significance to study the etiology of tetralogy of Fallot.
作者
田桂香(综述)
盛伟(审校)
Tian Guixiang;Sheng Wei(Children′s Hospital of Fudan University,Shanghai 201102,China)
出处
《国际儿科学杂志》
2020年第1期22-25,共4页
International Journal of Pediatrics
基金
国家重点研发计划项目(2016YFC1000500)
国家自然科学基金(81570282,81570283)。
