摘要
目的探讨卡马西平致药物超敏反应综合征(drug induced hypersensitivity syndrome,DIHS)的临床特点。方法回顾分析株洲市中心医院2例卡马西平致DIHS病例,结合文献对卡马西平致DIHS的临床表现、发病机制以及预防、治疗进行分析。结果2例病人因治疗癫痫或预防癫痫服用卡马西平片0.2 g,1天3次;用药2~3周出现DIHS。2例病人均予糖皮质激素治疗,病例1单用糖皮质激素即缓解,病例2联用糖皮质激素和人免疫球蛋白治疗后病情缓解。2例DIHS病情严重程度不同,糖皮质激素治疗疗程不同。结论卡马西平致DIHS临床表现多样;早期大剂量糖皮质激素治疗可有效控制症状,病情缓解后糖皮质激素减量应缓慢,并警惕复发。
Objective To explore the clinical features of drug induced hypersensitivity syndrome(DIHS)triggered by carbamaze pine.Methods We retrospectively analyzed 2 patients with DIHS triggered by carbamazepine in Zhuzhou Central Hospital and an alyzed its clinical manifestations,pathogenesis,prevention and treatment.Results The two patients developed DIHS(0.2 g,three times a day)2 to 3 weeks after taking carbamazepine for the treatment of epilepsy or prevention of epilepsy.Both patients were treated with glucocorticoids,case 1 relieved with glucocorticoids alone,and case 2 relieved with a combination of glucocorticoids and human immunoglobulin.Two cases of DIHS had different severity,and the courses of treatment with glucocorticoids for the two cases were also different.Conclusions The clinical manifestations of DIHS triggered by carbamazepine are diverse.Early high dose glucocorticoid therapy can effectively control the symptoms.The glucocorticoid reduction should be slow after the disease is re lieved,and the relapse should be on the alert.
作者
郭英
谭秋红
黄丽
GUO Ying;TAN Qiuhong;HUANG Li(Department of Pharmacy,Zhuzhou Central Hospital,Zhuzhou,Hunan 412000,China)
出处
《安徽医药》
CAS
2020年第4期842-845,共4页
Anhui Medical and Pharmaceutical Journal
关键词
卡马西平/副作用
疹
药物过敏
地塞米松
癫痫
文献复习
Carbamazepine/adverse effects
Exanthema
Drug hypersensitivity
Dexamethasone
Epilepsy
Literature review
