摘要
目的研究地屈孕酮联合二甲双胍治疗多囊卵巢综合征(PCOS)及对糖脂代谢、性激素及肥胖指标的影响。方法选择2015年1月至2018年12月我院收治的PCOS患者106例,按照随机数字表法分为试验组与对照组各53例。对照组给予地屈孕酮治疗,试验组给予地屈孕酮联合二甲双胍治疗。观察两组治疗前后血清睾酮(T)、雌二醇(E2)、促黄体生成素(LH)、卵泡雌激素(FSH)等性激素水平,血清瘦素(LEP)、内脂素(VF)及腰臀比、BMI等肥胖指标,空腹胰岛素(FINS)、空腹血糖(FPG)、胰岛素抵抗指数(HOMA-IR)等血糖代谢指标,甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等血脂代谢指标。治疗后6个月内妊娠情况。结果治疗后,试验组血清T、E2、LH、FSH、LEP、VF水平及腰臀比、BMI、FINS、FPG、HOMA-IR均低于对照组(P<0.05);血清TG、TC均低于对照组,HDL-C、LDL-C均高于对照组(P<0.05);试验组总有效率、治疗后6个月内妊娠率高于对照组(P<0.05)。结论地屈孕酮联合二甲双胍治疗POCS可有效纠正糖脂代谢紊乱,缓解胰岛素低抗,改善患者血糖、血脂及性激素水平,总有效率、妊娠率高,值得临床应用。
Objective To investigate the treatment of polycystic ovary syndrome(POCS)with dydrogesterone combined with metformin and its effects on glucose and lipid metabolism,sex hormones and obesity.Methods One hundred and six PCOS patients admitted to our hospital from January 2015 to December 2018 were divided into experimental or control group according to the random number table,53 in each group.The control group was treated with dydrogesterone and the experimental group was treated with dydrogesterone combined with metformin.Before and after treatment,serum levels of sex hormones including testosterone(T),estradiol(E2),luteinizing Hormone(LH)and follicular stimulating hormone(FSH),levels of obesity indicators including serum levels of leptin(LEP)and visfatin(VF),waist-hip ratio and BMI,levels of blood glucose metabolism indicators such as fasting insulin(FINS),fasting plasma glucose(FPG),homeostasis model assessment-insulin resistance(HOMA-IR)and levels of blood lipid metabolism indicators such as triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)were recorded.In addition,pregnancy within 6 months after treatment was observed.Results After of treatment,the levels of T,E2,LH,FSH,LEP,VF and waist-hip ratio,BMI,FINS,FPG,HOMA-IR in the experimental group were lower than those in the control group(P<0.05).Serum TG and TC in the experimental group were lower than those in the control group while HDL-C,LDL-C in the experimental group were higher than those in the control group(P<0.05).The total effective rate and pregnancy rate within 6 months after treatment were higher in the experimental group than those in the control group(P<0.05).Conclusion Treatment of POCS with dydrogesterone combined with metformin can effectively correct the disorders of glucose and lipid metabolism,relieve the IR,and improve the patients'blood glucose,blood lipid,and sex hormone levels with high total effective rate and pregnancy rate.It is worthy of clinical application.
作者
马景卉
罗娟
祝润
许丽丽
MA Jing-hui;LUO Juan;ZHU Run;XU Li-li(Department of Obstetrics and Gynecology,Pengshan District People's Hospital,Meishan 620860,China;Department of Obstetrics and Gynecology,Wuhou District People's Hospital,Chengdu 610041,China)
出处
《实用医院临床杂志》
2020年第2期198-201,共4页
Practical Journal of Clinical Medicine
关键词
地屈孕酮
二甲双胍
多囊卵巢综合征
糖脂代谢
性激素
肥胖
Dydrogesterone
Metformin
Polycystic ovary syndrome
Glucose and lipid metabolism
Sex hormones
Obesity
