摘要
目的观察布托啡诺联合右美托咪定超前镇痛对于麻醉苏醒期躁动的影响。方法择期在全麻下行开腹手术的患者80例,采用随机数字表法将其分为两组,每组40例。右美托咪定组(D组)患者在术前给予布托啡诺2mg并开始以0.5μg/kg静脉输注右美托咪定至手术开始时。生理盐水组(C组)在同一时间点给予生理盐水2mg并且以同等剂量开始输注右美托咪定至手术开始时。记录两组患者的一般情况,术中特定时间点的血压及心率总体波动幅度变化。患者在PACU期间的拔管时间、躁动分级评分及Riker镇静躁动评分。术后患者的视觉模拟疼痛评分,术后的不良事件发生率的情况。结果在T1-T4时刻,D组患者的收缩压、舒张压及心率值明显低于C组(P<0.05),差异有统计学意义。D组的躁动分级、VAS评分及Riker镇静躁动评分较C组低(P<0.05),差异有统计学意义。两组之间的不良事件(恶心、呕吐、昏迷、呼吸抑制)差异无统计学意义(P>0.05)。结论布托啡诺联合右美托咪定超前镇痛可以有效减少患者麻醉苏醒期躁动的发生。
Objective It observes the effect of butorphanol combined with dexmedetomib on preemptive agitation during anesthesia recovery.Methods 80 patients with open surgery under general anesthesia were randomly divided into two groups,which is 40 patients in each group.Patients in dexmedetomidine group(group D)were given butorphanol 2 mg before operation and began to infuse dexmedetomidine 0.5μg/kg intravenously until the beginning of operation.The patients in normal saline group(Group C)were given 2 mg of normal saline at the same time and started to infuse dexmedetomidine at the same dose until the beginning of the operation.The general situation of the patients in the two groups,overall fluctuations of blood pressure and heart rate at specific time points during the operation were recorded;the extubation time,agitation grade and SAS grade during the PACU period,the visual analog pain score of the patients after the operation,the incidence of adverse events after the operation were recorded.Results At the time of T1、T2、T3、T4,the SBP、DBP and heart rate were significantly lower in group D than in group C(P<0.05).The agitation grade,agitation degree,VAS score and SAS score in group D were lower than those in group C(P<0.05).There was no significant difference in adverse events(nausea,vomiting,coma and respiratory depression)between the two groups(P>0.05).Conclusion The treatment of butorphanol combined with dexmedetomidine can effectively reduce the incidence of agitation during anesthesia recovery.
作者
高蓝天
李春萍
GAO Lan-tian;LI Chun-ping(Department of Anesthesiology,The First Hospital of Jilin University,Changchun 130021,China)
出处
《中国实验诊断学》
2020年第3期418-421,共4页
Chinese Journal of Laboratory Diagnosis
