摘要
目的观察重组人干扰素α2b雾化联合金振口服液治疗治疗手足口病的临床疗效。方法选择2017年6月至2018年6月收治的168例手足口病患儿,随机分为对照组和试验组,每组84例。2组患儿均予一般治疗,对照组给予重组人干扰素α2b雾化治疗,喷雾喷入鼻腔和咽喉,每隔12小时1次;试验组在给予重组人干扰素α2b雾化治疗的基础上,加入金振口服液治疗。比较2组患儿的临床疗效以及退热、手足疱疹消退、口腔溃疡愈合时间以及平均住院时间。结果观察组临床症状体征改善及平均住院时间较对照组明显缩短(P均<0.05),且临床疗效优于对照组(χ2=10.971,P=0.001)。结论重组人干扰素α2b雾化联合金振口服液对于手足口病可起到良好的功效,显著改善临床症状,安全性高,用药方便,值得推广使用。
Objective To investigate the therapeutic effects of recombinant human interferonα2b atomization combined with Jinzhen oral liquid on hand-foot-mouth disease(HFMD).Methods A total of 168 children with HFMD who were admitted and treated in our hospital from June 2017 to June 2018 were randomly divided into control group and observation group,with 84 cases in each group.The patients in both groups were given general treatment.On that basis the patients in control group were treated by recombinant human interferonα2b atomization,spraying into nasal cavity and throat,once at an interval of 12 hours,however,the patients in observation group,on the basis of control group,wer etreated by Jinzhen oral liquid.The pyretolysis time,the time of hand and foot herpes regression,the healing time of oral ulcer healing time and the average hospitalization time were observed and compared between the two grousp.Results The improvement time of clinical symptoms and average hospitalization time in observation group were significantly shorter than those in control group(P<0.05).Moreoverthe therapeutic effects in observation group were significantly better than those in control group(P<0.01).Conclusion Human interferonα2b atomization combined with Jinzhen oral liquid has significant therapeutic effects on HFMD,which can significantly improve the clinical symptoms of patients,with higher safety and convenient medication,therefor,is worth popularizing in clinical practice.
作者
谭丽琴
韩玉兰
周林英
韦冰梅
TAN Liqin;HAN Yulan;ZHOU Linying(Department of Pediatrics,The Second Hospital Affiliated to Guangxi Medical University,Guangxi,Nanning 530007,China)
出处
《河北医药》
CAS
2020年第6期917-919,共3页
Hebei Medical Journal
基金
广西壮族自治区中医药管理局中医药民族医药自筹经费科研课题(编号:gzzc1141)。
关键词
重组人干扰素Α2B
金振口服液
手足口病
recombinant human interferon alpha 2b
Jinzhen oral liquid
Hand-foot-mouth disease
