摘要
目的探讨γ谷氨酰胺转移酶(γ-GT)、胆碱酯酶(CHE)、爱帕琳肽(Apelin)、内脂素(Visfatin)对非酒精性脂肪肝病(NAFLD)的临床诊断价值以及Apelin和Visfatin水平变化对血清γ-GT、CHE水平的影响。方法选取2014年6月-2019年6月淳安县第一人民医院消化内科门诊确诊的非酒精性脂肪肝病患者50例作为NAFLD组,另选取同时期进行体检的健康者50例作为对照组,2组患者均接受静脉抽血和血生化检查,比较2组血生化检查指标水平的差异;此外,分别对Apelin(γ-GT、CHE)和Visfatin(γ-GT、CHE)4组随机变量进行两两配对的Person线性检验。结果①NAFLD组患者血清γ-GT、CHE、Apelin水平高于对照组,NAFLD组血清内脂素水平低于对照组,差异有统计学意义(t=35.294、29.373、50.727、37.009,均P<0.001);②NAFLD组Apelin水平与γ-GT(r=0.676)、CHE(r=0.699)水平呈正相关(均P<0.05);内脂素水平与γ-GT(r=-0.731)、CHE(r=-0.698)水平呈负相关(均P<0.05)。结论非酒精性脂肪肝患者的γ-GT、CHE、Apelin、内脂素水平对于NAFLD的临床诊断具有参考价值;Apelin是NAFLD发生的可能诱发因素,而内脂素则是NAFLD发生的保护因素,对于NAFLD的预防治疗也具有临床价值。
Objective To explore the clinical diagnostic value of serum gamma-glutamine transferase(γ-GT), cholinesterase(CHE), Apelin and visfatin for nonalcoholic fatty liver disease(NAFLD), and the effect of the changes of Apelin and visfatin on the levels of γ-GT and ChE in serum. Methods Fifty patients with NAFLD diagnosed in the Department of Gastroenterology in our hospital from June to September 2019 were selected as NAFLD group. A total of 50 healthy subjects who underwent physical examination in our hospital at the same time were selected as control group. Patients received venous blood and blood biochemical tests, and the differences in blood biochemical tests(γ-GT, CHE, Apelin, and Visfatin) were compared between the two groups. The Apelin(γ-GT, CHE) and Visfatin(γ-GT, CHE) four sets of random variables were used to perform pairwise-pairwise Person linear test. Results ① The levels of serum γ-GT, CHE and Apelin in the NAFLD group were higher than those in the control group. The serum visfatin level in the NAFLD group was lower than that in the control group(t=35.294, 29.373, 50.727, 37.009, all P<0.001). ② The level of Apelin in NAFLD group was significantly positively correlated with the changes of γ-GT(r=0.676) and CHE(r=0.699, all P<0.05). The visfatin level was negatively correlated with the γ-GT(r=-0.731), the CHE(r=-0.698, all P<0.05). Conclusion The levels of γ-GT, CHE, Apelin and visfatin in patients with NAFLD have reference value for the clinical diagnosis of NAFLD. Apelin is a possible inducer of NAFLD, while visfatin is a protective factor of NAFLD, and also has clinical value for the prevention and treatment of NAFLD.
作者
洪文忠
李奕萍
HONG Wen-zhong;LI Yi-ping(Department of Clinical Laboratory,the First People's Hospital of Chun'an County,Hangzhou,Zhejiang 311700,China)
出处
《中华全科医学》
2020年第3期463-466,共4页
Chinese Journal of General Practice
基金
浙江省医药卫生科技计划项目(2018KY660)。
