摘要
[目的]研究肌成束蛋白-1(FSCN1)在上皮性卵巢癌组织中的表达及与预后相关性。[方法]选取2010年1月至2014年12月我院收治的120例卵巢肿瘤患者作为研究对象,包括80例上皮性卵巢癌,40例卵巢良性上皮肿瘤。采用免疫组化检测FSCN1在癌组织、癌旁组织和良性组织中的表达水平。免疫组化检测上皮间质转化(epithelial mesenchymal transformation,EMT)关键蛋白波形蛋白(vimentin)和E钙黏蛋白(E-cadherin)在卵巢癌组织中的表达水平。[结果]FSCN1在卵巢癌组织中的高表达率(67.5%,54/80)明显高于癌旁组织(28.8%,21/73)和良性卵巢组织(12.5%,5/40)(χ^2=41.02,P<0.001)。FSCN1表达水平与临床病理分期、淋巴结转移具有相关性(P=0.023;P=0.026),FSCN1表达水平与Vimentin表达水平呈正相关(P=0.007),而与E-cadherin表达水平呈负相关(P=0.006)。FSCN1高表达水平患者总生存率(27.5%)明显低于FSCN1低表达水平的患者(52.3%)(P=0.007),FSCN1高表达是上皮性卵巢癌患者不良预后的独立风险因素(P=0.011)。[结论]FSCN1在上皮性卵巢癌中高表达,且与卵巢癌的恶性程度密切和EMT相关,对于预测卵巢癌的预后具有一定的价值。
[Objective]To investigate the expression and clinical significance of fascin-1(FSCN1)in epithelial ovarian cancer.[Methods]One hundred and twenty patients with ovarian lesions admitted in our hospital from January 2010 to December 2014 were enrolled,including 80 cases of epithelial ovarian cancer and 40 cases of benign ovarian tumor.The protein expression levels of FSCN1 were detected by immunohistochemistry(IHC)in the ovarian carcinoma tissue,adjacent tissue and benign tumor tissue.IHC was also used to detect the expression of vimentin and E-cadherin,the key epithelial mesenchymal transformation(EMT)molecules.The relationships between FSCN1 expression and clinicopathological futures,EMT molecules and prognosis were analyzed.[Results]The expression rate of FSCN1 in ovarian cancer tissues(67.5%,54/80)was significantly higher than that in adjacent tissues(28.8%,21/73)and benign ovarian tissues(12.5%,5/40)(χ^2=41.02,P<0.001).FSCN1 expression was correlated with FIGO stage and lymphatic invasion(P=0.023;P=0.026).FSCN1 expression was positively correlated with vimentin expression(P=0.007)and negatively correlated with E-cadherin expression(P=0.006).The Kaplan-Meier survival analysis showed that the survival rate of patients with high FSCN1 expression levels(27.5%)was significantly lower than that with low FSCN1 expression(52.3%,P=0.007)and FSCN1 was an independent risk factor for poor prognosis(P=0.011).[Conclusion]FSCN1 is highly expressed in epithelial ovarian carcinoma and it is correlated with malignant degree and EMT,indicating that FSCN1 may serve as an independent prognostic marker for epithelial ovarian cancer.
作者
薛玲
岳丽娟
XUE Ling;YUE Li-juan(Hanzhong Central Hospital,Hanzhong 723000,China)
出处
《肿瘤学杂志》
CAS
2020年第3期220-223,共4页
Journal of Chinese Oncology
基金
陕西省重点研发项目(2017SF-074)。
