摘要
心血管疾病是当今时代最常见的疾病之一,也是发生急性死亡的主要疾病之一,虽然有规范的治疗方案,但心血管疾病患者的死亡率不但未下降,反而有上升的趋势。目前越来越多的研究发现,肠道菌群与心血管疾病有密切的关系,其中肠道菌群的代谢产物——三甲胺-N-氧化物被认为是影响心血管疾病的重要危险因素。现通过总结三甲胺-N-氧化物与冠心病和心力衰竭之间的关系,以及调节肠道菌群和改变其代谢产物三甲胺-N-氧化物后,对冠心病和心力衰竭发展的影响做一综述。
Cardiovascular disease is one of the most common diseases in today s era,and it is also one of the main diseases that cause acute death.Although there are standard treatment programs,the mortality rate of cardiovascular disease patients has not declined,but has an upward trend.At present,more and more studies have found that there is a close relationship between gut microbiota and cardiovascular disease.Trimethylamine-N-oxide(TMAO),the metabolite of gut microbiota,has been proved as an important risk factor for cardiovascular disease.Therefore,this article reviews the relationship between TMAO and coronary heart disease and heart failure,and after regulating intestinal flora and changing its metabolites TMAO,it will affect the development of coronary heart disease and heart failure.
作者
李靖
任彭
努尔比耶·麦麦提
赵增
LI Jing;REN Peng;Nuerbiye·Maimaiti;ZHAO Zeng(Graduate School of Xinjiang Medical University,Urumqi 830000,Xinjiang,China;Department of Cardiology,People s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,Xinjiang,China)
出处
《心血管病学进展》
CAS
2020年第3期272-276,共5页
Advances in Cardiovascular Diseases
关键词
肠道菌群
三甲胺-N-氧化物
冠心病
心力衰竭
Gut microbiota
Trimethylamine-N-oxide
Coronary heart disease
Heart failure
