摘要
盖塔病毒(GETV)是一种经蚊虫传播的虫媒病毒,可引起猪、马等家畜疾病,也可导致人类感染。目前,我国已从至少15个省(直辖市、自治区)的蚊虫、蠓、猪和狐狸中共分离到约70株GETV,三带喙库蚊和骚扰阿蚊是主要传播媒介。最近研究表明,GETV可分为4个进化种群(Group I、II、III和IV),其中Group I和II分别为马来西亚(1955年)和日本(1956年)早期流行株;Group III几乎包括1960年以来我国及其他国家所有分离株;Group IV于近期在我国云南省和俄罗斯远东地区被发现。空间动力学研究认为,马来西亚、日本和中国云南省是3个主要的GETV播散来源,而云南省是GETV迁徙事件发起的重要地区及中国内陆省份GETV循环的源泉地区。近几年调查还证实,我国湖南、河南、四川等省猪场猪群以及山东省饲养场狐狸中存在盖塔病毒病的流行,并从流行区猪、牛等家畜以及发热病人和健康人血清中检测到该病毒特异性抗体,表明GETV在我国流行广泛,是当前我国需要关注的重要公共卫生问题。
Getah virus(GETV)is a mosquito-borne virus that can cause livestock disease such as pigs and horses,and can also lead to human infection.At present,a total of about 70 strains of GETV have been isolated from mosquitoes,midges,pigs and foxes in least 15 provinces of China,Culex tritaeniorhynchus and Armigeres subalbatus mosquitoes are the main transmission vector.Recent studies have shown that the Most Recent Common Ancestor(MRCA)of GETV existed about 145 years and gradually evolved into four distinct evolutionary populations(Groups Ⅰ,Ⅱ,Ⅲ and Ⅳ).Group Ⅰ and Ⅱ were the early isolated strains in Malaysia(1955)and Japan(1956)respectively,and the Group Ⅲ included nearly all isolates from China and other countries since the 1960s as well as the Group Ⅳ has only recently been found Yunnan province of China and in the Far Eastern District of Russia.According to the spatial dynamics,Malaysia,Japan and Yunnan Province of China are the three main sources of GETV dispersal,while Yunnan Province is an important region for the origin of the GETV migration event,and also a source region for the GETV transmission cycle in provinces of inland China.In recent years,Getah virus disease epidemic has also been confirmed in pig herds in Hunan,Henan and Sichuan provinces of China and feedlot foxes in Shandong Province of China as well as specific antibody against GETV have been detected from sera of domestic animal,fever patients and healthy human in epidemic areas of GETV.These studies show that GETV is widely distributed in China,which is an important public health issue.
作者
张海林
胡挺松
张富强
ZHANG Hai-lin;HU Ting-song;ZHANG Fu-qiang(Center for Disease Control and Prevention of Southern Theater Command,Kunming 650118,China)
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2020年第3期229-233,244,共6页
Chinese Journal of Zoonoses
基金
国家十三五重点研发计划项目(No.2017YFD0501800)资助。
关键词
盖塔病毒
传播媒介
盖塔病毒病
流行病学
getah virus
transmitting vector
getah virus disease
epidemiology
