摘要
目的:探究重度子痫前期患者血清正五聚蛋白3(PTX3)含量与妊娠结局的相关性。方法:选取2018年1月-2019年1月笔者所在医院收治的重度子痫前期患者80例为研究组,并选取同期于笔者所在医院建档并体检的正常孕产妇30例作为对照组。统计两组受试者的一般临床资料,比较两组受试者血清PTX3的含量,研究组患者根据血清PTX3水平由低到高按三分位法分组:低(27例)、中(27例)与高(26例),分析三组患者的妊娠结局。结果:两组受试者的年龄、孕周、体重及BMI等一般临床资料相比差异无统计学意义(P>0.05);且与对照组相比,研究组患者的收缩压及舒张压显著增加(P<0.05);对照组受试者血清中PTX3含量为(2.83±0.59)ng/ml,研究组患者血清中PTX3含量为(8.19±1.05)ng/ml,与对照组相比,研究组血清中PTX3含量显著升高(P<0.05);与低水平患者及中水平患者相比,高水平组患者不良妊娠发生率显著增加(P<0.05)。结论:重度子痫前期患者血清PTX3显著增加,且其含量越高不良妊娠结局发生率越高,在治疗的过程中应注意降低PTX3的含量。
Objective:To explore the correlation between serum n-pentamerin 3(PTX3)and pregnancy outcome in patients with severe preeclampsia.Method:A total of 80 patients with severe preeclampsia admitted to our hospital from January 2018 to January 2019 were selected as the study group,and 30 normal pregnant women who were filed and examined in our hospital at the same time were selected as the control group.The general clinical data of the two groups were statistically analyzed.The serum PTX3 content of the two groups were compared.The patients in the study group were divided into three groups according to the level of serum PTX3:low(27 cases),middle(27 cases),high(26 cases).The pregnancy outcomes of the three groups were analyzed.Result:There was no significant difference between the two groups in age,gestational age,BMI and other general clinical data(P>0.05).Compared with the control group,the systolic and diastolic blood pressure in the study group increased significantly(P<0.05).The serum PTX3 content in the control group was(2.83±0.59)ng/ml,the serum PTX3 content in the study group was(8.19±1.05)ng/ml,compared with the control group,the level of PTX3 in the study group increased significantly,and the incidence of adverse pregnancy in the high-level group increased significantly(P<0.05).Conclusion:The serum PTX3 of severe preeclampsia patients increased significantly(P<0.05),and the higher the content of PTX3,the higher the incidence of adverse pregnancy outcome.Attention should be paid to reduce the content of PTX3 in the process of treatment.
作者
江国花
谭小平
钱莹
钟敏
JIANG Guohua;TAN Xiaoping;QIAN Ying;ZHONG Min(Shenzhen Longhua District People’s Hospital,Shenzhen 518109,China;不详)
出处
《中外医学研究》
2020年第6期4-6,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
深圳市龙华区科技创新资金项目(项目编号:2017044)。
