摘要
目的探讨大血小板比率(the rate of large platelets,PLCR)及脑卒中危险因素在高危脑卒中患者的动脉斑块病变中的影响。方法回顾性研究2016年-2018年在余姚人民医院就诊的脑卒中高危患者,根据彩色多普勒超声诊断仪检查颈动脉粥样斑块的数量,同时采用全自动生化分析仪检测患者血脂、血糖等相关生化指标以及用血细胞分析仪测定血小板相关参数包括血小板数量(platelet,PLT)、血小板平均体积(mean platelet volume,MVP)、PLCR等指标,并按照PLCR水平为3组。结果 PLCR是脑卒中高危患者动脉斑块病变的独立危险因素(OR=1.110,95%CI:1.031~1.195,P=0.006)。PLCR高水平组合并脑卒中危险因素的颈动脉斑块的形成率均高于PLCR低水平和中水平合并脑卒中危险因素组(P<0.05)。结论脑卒中高危人群大血小板比率的水平与动脉斑块密切相关,尤其在合并脑卒中相关危险因素后将进一步影响动脉斑块的形成。
Objective To investigate the relationship between the rate of large platelets(PLCR) and carotid plaque in high risk stroke population.Methods A retrospective study was conducted on the stroke patients at high risk in Yuyao People’s Hospital from 2016 to 2018.The number of carotid atherosclerotic plaques was checked using a color Doppler ultrasound system.A full-automatic biochemical analyzer was used to detect patients ’ blood lipids,blood glucose and other related biochemical indicators;platelet-related parameters were measured using a blood cell analyzer,including platelet number(PLT),mean platelet volume(MVP),and PLCR.These parameters were divided into three groups based on PLCR levels.Results PLCR is an independent risk factor for arterial plaque lesions in high-risk stroke patients(OR = 1.110,95% Cl:1.031-1.195,P = 0.006).The formation rate of carotid plaque in high-level PLCR combination and stroke risk factors was higher than that in low-and medium-level PLCR combined stroke risk factor group(P<0.05).Conclusion The level of large platelet ratio in high-risk stroke populations is closely related to arterial plaque;when it is combined with stroke,related risk factors will further affect the formation of arterial plaque.
作者
严玲利
YAN Ling-li(Clinical Laboratory,Yuyao People's Hospital,Yuyao,Zhejiang 315400,China)
出处
《中国卫生检验杂志》
CAS
2020年第5期597-600,共4页
Chinese Journal of Health Laboratory Technology
关键词
脑卒中
高危人群
颈动脉斑块
大血小板比率
Stroke
High-risk population
Carotid plaque
The rate of large platelets
