摘要
TRIM家族是一类大多具有E3泛素连接酶活性的蛋白,参与许多重要的生物学过程,包括细胞内信号转导、蛋白的质量控制、先天免疫、自噬和癌变。近年来的研究发现,TRIM蛋白表达的失调会导致多种疾病,例如:肿瘤、免疫性疾病、神经精神疾病、传染性疾病、染色体异常及发育性疾病等。TRIM3是TRIM家族成员之一,主要由N末端的RING结构域、B-BOX结构域、卷曲螺旋结构域和C-末端结构域组成,它在多种肿瘤的发生及进展过程中发挥着重要的抑癌作用,如胶质母细胞瘤,肝癌和结直肠癌(colorectal cancer,CRC)等。目前主要认为TRIM3是一种候选肿瘤抑制基因,它可以抑制肿瘤细胞生长、侵袭与转移,与肿瘤的临床分期及预后关系密切。其作用机制涉及NF-κB信号通路、Musashi-Notch信号通路、P38信号通路等多条信号通路。
The TRIM family is a class of proteins that most of them have E3 ubiquitin ligase activity.They are involved in many important biological processes,including intracellular signal transduction,protein quality control,innate immunity,autophagy,and carcinogenesis.Recent studies found that TRIM protein expression defects can lead to a variety of diseases,such as tumor,immune diseases,neuropsychiatric diseases,infectious diseases,chromosomal abnormalities and developmental diseases.TRIM3,one member of the TRIM family,is composed of the N-terminal RING domain,B-BOX domain,coiled-coil domain and C-terminal domain.It plays an important tumor suppressive function in the development and progression of various tumors,such as glioblastoma,liver cancer and colorectal cancer.TRIM3 has been considered to be a candidate tumor suppressor gene,which can inhibit tumor cell growth,invasion and metastasis,and is closely related to the clinical stage and prognosis of the tumor.The mechanism of TRIM3 function involves multiple signaling pathways such as NF-κB signaling pathway,Musashi-Notch signaling pathway and P38 signaling pathway.
作者
从雨
徐娟(综述)
贾雪梅(审校)
CONG Yu;XU Juan;JIA Xuemei(Department of Gynecology,Women’s Hospital of Nanjing Medical University(Nanjing Maternity and Child Health Care Hospital),Nanjing 210011,China)
出处
《临床与病理杂志》
2020年第3期728-733,共6页
Journal of Clinical and Pathological Research
基金
国家自然科学基金(81602285)。
