摘要
目的比较不同剂量阿托伐他汀治疗老年动脉粥样硬化(atherosclerosis,AS)性脑梗死的疗效及安全性。方法选取2018年9月至2019年7月就诊于我院的老年AS性脑梗死患者100例,随机分为对照组(n=50)和观察组(n=50),对照组予以阿托伐他汀钙片20 mg/d,观察组予以阿托伐他汀钙片40 mg/d。两组均连续治疗14 d。比较两组临床疗效、凝血功能、糖脂代谢指标及血清同型半胱氨酸(homocysteine,Hcy)、C反应蛋白(C-creative protein,CRP)、淀粉样蛋白A(serum amyloid A,SAA)水平,并观察两组不良反应。结果治疗总有效率,观察组为88.00%,对照组为82.00%,组间对比差异无统计学意义(P>0.05)。治疗后,两组凝血酶原时间、凝血酶时间及纤维蛋白原相比治疗前均明显改变(P>0.05),组间比较差异无统计学意义(P>0.05)。治疗后,观察组空腹血糖、餐后2 h血糖、总胆固醇、三酰甘油、低密度脂蛋白及血清Hcy、CRP、SAA水平均明显低于对照组(P<0.05),高密度脂蛋白明显高于对照组(P<0.05)。两组不良反应比较差异无统计学意义(P>0.05)。结论40mg/d的阿托伐他汀治疗老年AS性脑梗死的疗效与20 mg/d的阿托伐他汀相当,但能够更好地改善糖脂代谢、减轻炎症反应,且安全性良好。
Objective To compare the efficacy and safety between different doses of atorvastatin in the treatment of atherosclerotic(AS)cerebral infarction in the elderly.Methods 100 elderly patients with AS cerebral infarction who were admitted to the hospital between September,2018 and July,2019 were selected and randomly divided into the control group(n=50)and the observation group(n=50).The control group were treated with 20 mg/d of atorvastatin calcium tablets,while the observation group were treated with 40 mg/d of atorvastatin calcium tablets.Both groups were treated continuously for 14 days.The clinical efficacy,coagulation function,levels of glycolipid metabolism indexes,serum homocysteine(Hcy),C-reactive protein(CRP)and amyloid protein A(SAA)were compared between the two groups.Adverse reactions from both groups were also observed.Results The total effective rate of treatment was 88.00%in the observation group and 82.00%in the control group,showing no significant difference between groups(P>0.05).There were significant differences in prothrombin time,thrombin time and fibrinogen within both groups before and after treatment(P>0.05),but no significant difference between the two groups(P>0.05).After treatment,levels of fasting blood glucose,postprandial 2h blood glucose,total cholesterol,triglyceride,low-density lipoprotein,serum Hcy,CRP and SAA levels in the observation group were significantly lower than those in the control group(P<0.05),while high-density lipoprotein was significantly higher than the control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The efficacy of 40 mg/d of atorvastatin is similar to that of 20 mg/d of atorvastatin in the treatment of elderly patients with AS cerebral infarction.However,the former can better improve glycolipid metabolism and relieve inflammation,with safety.
作者
罗小兰
罗晓静
LUO Xiaolan;LUO Xiaojing(Department of Neurology,Ya′an People′s Hospital,Ya′an 625000,China)
出处
《标记免疫分析与临床》
CAS
2020年第2期224-228,共5页
Labeled Immunoassays and Clinical Medicine
基金
四川省科技厅资助项目(编号:2015005162)。
