摘要
目的分析肠外营养治疗的溃疡性结肠炎患者低钙血症发生率及其相关因素。方法选取2016年1月至2018年1月攀枝花市第二人民医院收治的90例溃疡性结肠炎患者,均给予肠外营养治疗,观察低血钙发生情况,并对患者年龄、性别、日照时间、BMI、疾病活动指数(disease activity index,DAI)及血液学指标等进行分析。结果发生低血钙者27例(低钙血症组),未发生低血钙者63例(对照组),低血钙发生率为30.00%。2组性别、日照时间、BMI、DAI及钙、镁、PLT、总蛋白(total protein,TP)、ALB、Hb、前白蛋白(prealbumin,PA)、活化PT、D-二聚体、PT、凝血酶时间(thrombin time,TT)、国际标准化比值(international normalized ratio,INR)、FIB和活化部分凝血活酶时间(activated partial thromboplastin time,APTT)等指标差异有统计学意义(P<0.05)。多因素logistic分析显示,日照时间<2 h/d和DAI评分≥8分是溃疡性结肠炎患者低钙血症发生的独立危险因素(P<0.05)。结论经肠外营养治疗的溃疡性结肠炎患者低钙血症的发生率较高,日照时间和DAI评分是影响疡性结肠炎患者低钙血症发生的独立危险因素,应积极控制结肠性溃疡的疾病活动度,并适当增加日照时间,以降低低钙血症的发生。
Objective To analyze the incidence and related factors of hypocalcemia in patients with ulcerative colitis treated with parenteral nutrition.Methods A total of 90 patients with ulcerative colitis treated in our hospital from January2016 to January 2018 were selected.All patients received parenteral nutrition treatment.The occurrence of hypocalcemia was observed.The age,gender,sunshine time,BMI,disease activity index(DAI)and hematological indexes of the patients were analyzed.Results There were 27 cases of hypocalcemia(hypocalcemia group)and 63 cases of non-hypocalcemia(control group).The incidence of hypocalcemia was 30.0%.There were significant differences between the two groups in gender,sunshine time,BMI,DAI,calcium,magnesium,platelet,total protein(TP),albumin,hemoglobin,prealbumin(PA),activated PT,D-dimer,PT,thrombin time(TT),INR,FIB,and activated partial thromboplastin time(APTT)(P<0.05).Multi factor logistic regression analysis showed that sunshine time less than 2 h and DAI score≥8 were independent risk factors for hypocalcemia in patients with ulcerative colitis were(P<0.05).Conclusions The incidence of hypocalcemia in patients with ulcerative colitis treated with parenteral nutrition is high.Sunshine time and DAI are independent risk factors for hypocalcemia in patients with ulcerative colitis.Therefore,we should actively control the disease activity of colonic ulcer and appropriately increase sunshine time to reduce the incidence of hypocalcemia.
作者
周顺军
胡文聪
Zhou Shunjun;Hu Wencong(Department of Gastroenterology,Second People's Hospital of Panzhihua City,Pan zhihua 617000,China)
出处
《北京医学》
CAS
2020年第2期106-108,112,共4页
Beijing Medical Journal
