摘要
细胞色素P450(CYP)是一组血红蛋白,在临床使用的药物和其他异生素的氧化代谢(第一阶段)中起着重要作用。CYP2B亚家族是CYP超家族的一个成员,目前在哺乳动物中的灵长目、啮齿目、食肉目、有蹄类及兔形目中都有发现。哺乳动物CYP2B是一种药物代谢酶,能代谢8%临床上重要药物,如抗肿瘤药物环磷酰胺和异环磷酰胺、抗逆转录病毒药物奈韦拉平和依法韦仑等,因此越来越受到人们的关注。本文主要对哺乳动物CYP2B亚家族基因的分布部位、药物代谢、同源性、诱导、抑制和基因多态性方面进行综述。
Cytochrome P450 (CYP) is a group of hemoglobins that play an important role in the oxidative metabolism (phase I) of clinically used drugs and other xenobiotics. The CYP2B subfamily is a member of the CYP superfamily and is currently found in mammals such as primates, rodents, carnivores, Ungulates and rabbits. The mammalian CYP2B is a drug-metabolizing enzyme that metabolizes 8 % clinically important drugs such as the antitumor drugs cyclophosphamide and ifosfamide, antiretroviral drugs nevirapine and efavirenz, etc., so it has received increasing attention. This article reviews the expression sites, drug metabolism, homology, induction inhibition and gene polymorphism of CYP2B subfamily genes in mammals.
作者
李家萍
Li Jiaping(Key Laboratory of Rare and Endangered Animal and Plant Ecology and Environmental Protection,Ministry of Education,Guangxi Normal University,Guilin 541006;College of Life Sciences,Guangxi Normal University,Guilin 541006,China)
出处
《广东化工》
CAS
2020年第5期103-104,108,共3页
Guangdong Chemical Industry
基金
2018年生态学博士点建设课题,哺乳动物CYP2家族基因的进化研究,2018.01-2018.12,EDPC2018003。
