摘要
聚(N-(2-羟丙基)甲基丙烯酰胺)(PHPMA)作为一种应用较广的水溶性聚合物,具有结构稳定性、非免疫原性以及良好的亲水性,可在人体中代谢,因此这种药物载体在过去几十年中被广泛运用于抗癌药物载药体系的研究。将PHPMA作为药物载体,连接不同功能基团,可使药物准确地在特定区域表达或释放,由此完成对疾病的检测或治疗。科学家进一步改进了载体的可降解性,降低了系统的细胞毒性,使这一体系获得更广阔的应用前景。目前为止只有少数的综述论文对这一领域进行了总结,几乎全部是从材料的生物功能方面进行阐述,而忽视了对材料制备方法的关注。为了弥补这一空白,本文从聚合物键合药物方式的独特分类视角,分别从共价键键合以及非共价键合的角度进行归纳整理,同时对于外界刺激可断裂型的材料进行了详细的论述,以期为科研工作者提供更多的启示。
Poly(N-(2-hydroxypropyl)methacrylamide)(PHPMA),a water soluble polymer bearing a stable structure,can be metabolized in the human body.Because of that,PHPMA is widely used in anticancer drug's delivery systems.The drug delivery systems based on the PHPMA have been extensively studied over the past few decades.Scientists use different kinds of functional groups to modify the polymer,which can deliver drugs to targeted tissue or detect pathogenic tissue.In recent studies,scientists enhance the degradability of the polymer and decrease the cytotoxicity,which makes the delivery system based on PHPMA more suitable to be utlized in human body.In this paper,we summarize the recent works about PHPMA and studies of different methods to modify the polymer with drugs or functional groups.
作者
张芬铭
田语舒
郑绩
陈堃
冯岸超
张立群
Fenming Zhang;Yushu Tian;Ji Zheng;Kun Chen;Anchao Feng;Liqun Zhang(State Key Laboratory of Organic-Inorganic Composites,Beijing University of Chemical Technology,Beijng 100029,China;Beijing Key Laboratory of preparation and processing of new polymer materials,Beijing University of Chemical Technology,Beijing 100029,China;College of Materials Science and Engineering,Beijing University of Chemical Technology,Beijing 100029,China)
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2020年第2期331-343,共13页
Progress in Chemistry
