摘要
目的:探讨解毒愈溃汤联合曲安奈德对糜烂型口腔扁平苔藓(EOLP)的治疗效果。方法:82例EOLP患者均分为观察组(常规治疗+解毒愈溃汤)和对照组(常规治疗),治疗12周;采用视觉模拟评分法(VAS)评估2组患者治疗前后口腔疼痛情况,采用口腔病损面评分系统(REU)评估2组患者治疗前后口腔黏膜病损面积,采用流式细胞仪检测2组患者治疗前后外周血T细胞免疫指标(CD+4、CD+8及CD+4/CD+8),采用酶联免疫吸附法(ELISA)检测2组患者治疗前后血清肿瘤坏死因子α(TNF-α)及白细胞介素-10(IL-10)水平,随访6个月比较2组显效和有效EOLP患者的复发情况。结果:观察组EOLP患者总有效率(92.68%)高于对照组(73.17%),差异有统计学意义(χ2=5.513,P<0.05);与治疗前相比,治疗后2组患者VAS评分和口腔黏膜病损面积均降低,且观察组明显低于对照组(P<0.01);与治疗前相比,治疗后2组患者外周血CD+4比例及CD+4/CD+8值升高,且观察组高于对照组(P<0.05);与治疗前相比,治疗后2组患者外周血CD+8比例明显降低(P<0.001),且观察组明显低于对照组(P<0.01);与治疗前相比,治疗后2组患者血清TNF-α和IL-10水平均明显下降,且观察组明显低于对照组(P<0.001);观察组患者的病情复发率(21.05%)明显低于对照组(56.67%),差异有高度统计学意义(χ2=9.146,P=0.002)。结论:解毒愈溃汤联合曲安奈德能够有效缓解EOLP患者的临床症状,其机制可能与改善患者的免疫功能、降低机体的炎症反应有关。
Objective:To explore the effect of jieduyukui decoction combined with triamcinolone acetonide on erosive oral lichen planus(EOLP).Methods:Eighty-two patients with EOLP were divided into the observation group(routine treatment+jieduyukui decoction)and the control group(routine treatment)and treated for 12 weeks.Visual analogue scale(VAS)was used to evaluate the oral pain and the area of oral mucosal lesions was evaluated by reticulation,erosion and ulceration scoring system(REU),flow cytometry was used to detect peripheral blood T cell immune indexes(CD+4,CD+8 and CD+4/CD+8),serum tumor necrosis factor-α(TNF-α)and interleukin-10(IL-10)levels were detected by enzyme linked immunosorbent assay(ELISA),and all the assessments were performed in the two groups before and after treatment.The clinical efficacy of the two groups after treatment and the relapse of the effective patients after 6 months’follow-up were compared.Results:The total effective rate in the observation group(92.68%)was higher than that in the control group(73.17%).The difference was statistically significant(χ2=5.513,P<0.05);After treatment,both VAS scores and oral mucosal lesion area in both groups decreased,significantly lower in the observation group than in the control group(P<0.01);The ratio of CD+4 and CD+4/CD+8 in peripheral blood of the two groups increased after treatment,higher in the observation group than in the control group(P<0.05);The ratio of CD+8 in peripheral blood in the two groups after treatment significantly decreased than before treatment(P<0.001),and that in the observation group was obviously lower than that in the control group(P<0.01);Serum TNF-αand IL-10 levels in both groups significantly decreased after treatment,obviously lower in the observation group than in the control group(P<0.001);The recurrence rate in the observation group(21.05%)was significantly lower than that in the control group(56.67%),with a statistically significant difference(χ2=9.146,P=0.002).Conclusion:Jieduyukui decoction combined with triamcinolone acetonide can effectively alleviate the clinical symptoms of patients with EOLP,enhance the immune function,and reduce the level of inflammatory factors,and the effect is significant.
作者
王蕊
王芹
杜文斌
张慧
马赛
胥爱文
汪佳
安峰
WANG Rui;WANG Qin;DU Wenbin;ZHANG Hui;MA Sai;XU Aiwen;WANG Jia;AN Feng(Department of Stomatology,the First Affiliated Hospital of Hebei Northern College,Zhangjiakou 075000,Hebei,China;Department of Stomatology,the Second Affiliated Hospital of Hebei Northern College,Zhangjiakou 075100,Hebei,China)
出处
《贵州医科大学学报》
CAS
2020年第3期335-339,344,共6页
Journal of Guizhou Medical University
基金
张家口市科学技术与地震局项目(1821059D)。
关键词
曲安奈德
治疗结果
糜烂型口腔扁平苔藓
解毒愈溃汤
中西医结合
血清肿瘤坏死因子-Α
白细胞介素-10
免疫功能
triamcinolone acetonide
treatment outcome
erosive oral lichen planus(EOLP)
jiedu-yukui decoction
combination between traditional Chinese and western medicine
serum tumor necrosis factor-α(TNF-α)
interleukin-10(IL-10)
immune function
