摘要
目的探讨山东省非霍奇金淋巴瘤(NHL)患者的临床病理特征。方法回顾性分析山东省肿瘤医院2002年1月至2017年12月收治的2886例NHL患者的临床病理资料,总结患者临床病理特征,并与我国其他地区及国外研究进行比较。结果所有患者中位发病年龄52岁(4~90岁),男女比为1.57∶1。全组中B细胞NHL(B-NHL)1925例(66.7%),T细胞NHL(T-NHL)788例(27.3%)。常见病理亚型包括弥漫大B细胞淋巴瘤(36.0%,1039/2886)、NK/T细胞淋巴瘤(8.8%,254/2886)、滤泡性淋巴瘤(8.2%,237/2886)和外周T细胞淋巴瘤(7.4%,214/2886)。所有患者病变位于淋巴结内1322例(45.8%),淋巴结外1564例(54.2%);Ⅰ期389例(13.5%),Ⅱ期678例(23.5%),Ⅲ期975例(33.8%),Ⅳ期722例(25.0%)。山东省淋巴瘤各亚型分布与国内多中心研究相一致,但T-NHL比例较国外研究高。结论我国山东省NHL总体发病以中年人群为主,B-NHL比例高于T-NHL。我国山东省NHL亚型分布特点不同于欧美国家,但与国内多中心研究大致相符。
Objective To investigate the clinicopathological characteristics of non-Hodgkin lymphoma(NHL)in Shandong province.Methods The clinicopathological data of 2886 NHL cases in Shandong Cancer Hospital from January 2002 to December 2017 were retrospectively analyzed,the clinicopathological characteristics of patients were summarized and compared with other regions in China and abroad.Results The median age of all NHL cases was 52 years old(4-90 years old),and the ratio of male to female was 1.57∶1.The subtypes distribution analysis revealed that B-cell NHL(B-NHL)accounted for 66.7%(1925 cases)of all cases and T-cell NHL(T-NHL)accounted for 27.3%(788 cases)of all cases.The common subtypes were diffuse large B-cell lymphoma(36.0%,1039/2886),NK/T-cell lymphoma(8.8%,254/2886),follicular lymphoma(8.2%,237/2886)and peripheral T-cell lymphoma(7.4%,214/2886).Of all the cases,the nodal lymphomas accounted for 45.8%(1322 cases)and the extra nodal lymphomas accounted for 54.2%(1564 cases);there were 389 patients(13.5%)with stageⅠ,678 patients(23.5%)with stageⅡ,975 patients(33.8%)with stageⅢ,and 722 patients(25.0%)with stageⅣ.The distribution of NHL subtypes in Shandong province was consistent with the domestic multicenter study.However,T-NHL subtype ratio was significantly higher than the foreign studies.Conclusions The overall incidence of NHL in Shandong province of China is dominated by middle-aged people,and the proportion of B-NHL is higher than that of T-NHL.The distribution of NHL subtypes in Shandong province of China are different from those in the European and American countries,but are roughly consistent with the domestic multicenter study.
作者
王体
张秋景
刘玉红
祝情情
孙菊杰
张建波
刘杰
宋宝
Wang Ti;Zhang Qiujing;Liu Yuhong;Zhu Qingqing;Sun Jujie;Zhang Jianbo;Liu Jie;Song Bao(Department of Internal Medicine 3,Shandong Cancer Hospital,Shandong First Medical University and Shandong Academy of Medical Sciences,Jinan 250117,Chin;Basic Laboratory,Shandong Cancer Hospital,Shandong First Medical University and Shandong Academy of Medical Sciences,Jinan 250117,China;Department of Oncology,Sishui County People's Hospital of Shandong Province,Sishui 273200,China)
出处
《白血病．淋巴瘤》
CAS
2020年第2期117-120,共4页
Journal of Leukemia & Lymphoma
基金
山东省科技攻关项目(2016GSF201043)
山东省自然科学基金(ZR2013HM079)
济南市科技发展计划(201202031)。
关键词
淋巴瘤
非霍奇金
诊断
病理分类
免疫表型
Lymphoma,non-Hodgkin
Diagnosis
Pathological classification
Immunophenotyping
