摘要
目的探讨雾霾细颗粒(PM2.5)对慢性阻塞性肺疾病(COPD)患者气道炎性反应的影响。方法选择2018年7-12月经民航总医院诊断为稳定期的COPD患者84例为调查对象,根据患者居住地区分成城区组(n=43例)和郊区组(n=41例),对比城区与郊区PM2.5平均浓度,分析城区组与郊区组受试者炎性反应、细胞学检验结果。结果 2018年7-12月北京市城区PM2.5均显著高于郊区(P<0.05)。两组患者比较,城区组患者肿瘤坏死因子α(TNF-α)、白介素-2(IL-2)、白介素-8(IL-8)及丙二醛(MDA)水平高于郊区组,转化生长因子β1(TGF-β1)低于郊区组(均P<0.05);城区组患者巨噬细胞及中性粒细胞检验结果高于郊区组(P<0.05)。结论雾霾细颗粒PM2.5可加重COPD患者的气道炎性反应,危及患者的身体健康,应对雾霾颗粒所致的健康损害提高警惕。
Objective To investigate the effect of haze granules on airway inflammation in patients with chronic obstructive pulmonary disease(COPD). Methods 84 COPD patients diagnosed as stable stage by CAAC General Hospital from July to December 2018 were selected as the subjects of study. According to the area where the patients lived,they were divided into urban group(n=43) and suburban group(n=41).The average concentration of PM2.5 in urban area and suburban area was compared,and the inflammatory reaction and cytological test results of subjects in urban and suburban groups were analyzed. Results From July 2018 to December2018,the average concentration of PM2.5 in urban area was significantly higher than that in suburban area(P<0.05). The levels of tumor necrosis factor-alpha(TNF-α),interleukin-2(IL-2),interleukin-8(IL-8) and malondialdehyde(MDA) in urban area were higher than those in suburban area,the level of transforming growth factor-beta1(TGF-β1) in urban area was lower than that in suburban area(all P<0.05).The results of macrophage and neutrophil test in urban group were significantly higher than those in suburban area(P<0.05). Conclusion Haze granules can aggravate airway inflammation in patients with COPD and endanger the health of the body.In clinical treatment,it is necessary to vigilant haze granules.
作者
张晓伟
李玉玲
李绪言
ZHANG Xiao-wei;LI Yu-ling;LI Xu-yan(Department of Infectious Diseases,General Hospital of Civil Aviation,Beijing,100123,China;Department of Respiration,Chaoyang Hospital,Beijing,100000,China)
出处
《职业与健康》
CAS
2020年第2期241-243,共3页
Occupation and Health
基金
首都卫生发展科研专项项目(2016-4-1063)。
关键词
雾霾颗粒
慢性阻塞性肺疾病
炎性反应
细胞学
Haze granules
Chronic obstructive pulmonary disease
Inflammatory reaction
Cytology
