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深刻理解烧创伤脓毒症发病机制的网络效应 被引量:16

A profound understanding of the pathogenesis network in sepsis
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摘要 严重烧创伤患者常并发脓毒症,进一步发展可导致多器官功能障碍综合征(MODS)。2016年,脓毒症被重新定义为机体对感染的反应失调而导致危及生命的器官功能障碍。脓毒发病机制复杂,涉及全身多系统功能失调,如炎症反应失控、免疫功能紊乱、凝血功能障碍、神经-内分泌-免疫系统功能紊乱等,参与因素众多并相互影响,形成复杂的非线性网络效应。在深刻解析脓毒症发病机制的基础上,进行多因素干预是未来脓毒症治疗的方向。
作者 张卉 冯永文 姚咏明 Zhang Hui;Feng Yongwen;Yao Yongming(Trauma Research Center,Fourth Medical Center of the Chinese PLA General Hospital,Beijing 100048,China;Intensive Care Unit,Second People′s Hospital of Shenzhen,Shenzhen 518035,China)
出处 《中华医学杂志》 CAS CSCD 北大核心 2020年第12期881-885,共5页 National Medical Journal of China
基金 国家自然科学基金(81730057,81871580) 国家重点研发计划(2017YFC1103302)。
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