摘要
To the Editor:Autosomal dominant polycystic kidney disease(ADPKD)is a common inherited kidney disease with an estimated incidence of 1 in 400 to 1 in 1000.[1] It is a late-onset systemic disorder characterized by the development and progressive enlargement of cysts in the kidney,eventually leading to end-stage renal disease.[2] Previous studies have shown that ADPKD is a heterogeneous monogenic disorder resulting from mutations in two genes:PKD1 and PKD2.Clinical data showed that PKD1 and PKD2 mutations account for 85% and 15% of ADPKD cases,respectively.[3]
基金
This work was supported by grants from the National Natural Science Foundation of China(No.81070131)
the Program for Liaoning Excellent Talents in University(No.LJQ2012069)
the Natural Science Foundation of Liaoning Province(No.201602852).
