摘要
目的分析左氧氟沙星治疗耐多药肺结核的效果与安全性。方法选取2018年1月~2019年1月在我院接受治疗的80例耐多药肺结核患者作为研究对象,采用随机列表法将其分为对照组(n=40)与观察组(n=40)。对照组患者接受常规药物治疗,观察组患者在对照组的基础上接受左氧氟沙星治疗。观察两组患者的治疗效果、治疗前后炎性因子[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-1(IL-1)]水平和不良反应总发生率。结果观察组患者的治疗总有效率为97.50%,高于对照组的82.50%,差异有统计学意义(P<0.05)。两组患者治疗后的TNF-α、IL-6、IL-1水平均低于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的TNF-α、IL-6、IL-1水平均低于对照组,差异有统计学意义(P<0.05)。在进行药物治疗期间,观察组患者的不良反应总发生率为15.00%,与对照组的12.50%比较,差异无统计学意义(P>0.05)。结论对耐多药肺结核患者实施左氧氟沙星治疗,能够显著降低炎性因子水平,提高治疗效果,同时患者的不良反应较少,具有较高的安全性,值得推广应用。
Objective To analyze the effect and safety of Levofloxacin in the treatment of multidrug-resistant pulmonary tuberculosis.Methods Eighty patients with multidrug-resistant pulmonary tuberculosis who were treated in our hospital from January 2018 to January 2019 were selected as the research objects,and they were divided into the control group(n=40)and the observation group(n=40)by the random list method.Patients in the control group received conventional drug treatment,and patients in the observation group received Levofloxacin treatment on the basis of the control group.The therapeutic effect,levels of inflammatory factors(tumor necrosis factor-α[TNF-α],interleukin-6[IL-6],interleukin-1[IL-1])before and after treatment and the total incidence rate of adverse reactions were observed in the two groups.Results The total effective rate of treatment in the observation group was 97.50%,which was higher than that in the control group accounting for 82.50%,and the difference was statistically significant(P<0.05).The levels of TNF-α,IL-6 and IL-1 after treatment in the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).The levels of TNF-α,IL-6 and IL-1 after treatment in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).During the drug treatment period,the total incidence rate of adverse reactions in the observation group was 15.00%,compared with 12.50%in the control group,and the difference was not statistically significant(P>0.05).Conclusion Levofloxacin in the treatment of patients with multidrug-resistant pulmonary tuberculosis can significantly reduce the level of inflammatory factors and improve the therapeutic effect.At the same time,patients have fewer adverse reactions and have higher safety,which is worthy of being promoted and applied.
作者
吴成波
WU Cheng-bo(Department of Thoracic Surgery,the Third People's Hospital of Shantou,Guangdong Province,Shantou 515073,China)
出处
《中国当代医药》
2020年第9期44-46,共3页
China Modern Medicine
关键词
耐多药肺结核
左氧氟沙星
治疗效果
不良反应
炎性因子
Multidrug-resistant pulmonary tuberculosis
Levofloxacin
Therapeutic effect
Adverse reactions
Inflammatory factors
