摘要
目的探讨妊娠早期孕妇低色素性贫血对糖化血红蛋白(HbA1c)水平的影响。方法回顾性分析2017年11月至2018年4月到该院产科建立生育档案的孕7~12周,空腹血糖(FPG)正常的孕妇544例,其中Hb≥110 g/L者(贫血组)346例,Hb<110 g/L者(非贫血组)198例,根据平均红细胞体积(MCV)和平均红细胞血红蛋白量(MCH)将选取的544例妊娠早期孕妇分为低色素组和正色素组。低色素组194例,其中小细胞低色素性贫血(MCV<82 fL,MCH<27 pg)173例,正细胞低色素性贫血(MCV≥82 fL,MCH<27 pg)21例;正色素组(MCV≥82 fL,MCH≥27 pg)350例,其中正细胞正色素性贫血76例,正细胞正色素非贫血274例。采用全自动血细胞分析仪、全自动生化分析仪和全自动糖化血红蛋白检测仪检测两组研究对象的血常规、FPG和HbA1c水平,并将结果进行比较和分析。结果非贫血组与贫血组孕妇FPG水平分别为(4.93±0.99)、(4.99±2.16)mmol/L,差异无统计学意义(t=-0.409,P=0.683),HbA1c水平分别为(5.53±0.56)%、(5.58±0.55)%,差异无统计学意义(t=-0.960,P=0.338);低色素组(MCH<27 pg)和正色素组(MCH≥27 pg)孕妇FPG水平分别为(4.97±2.19)、(4.94±0.98)mmol/L,差异无统计学意义(t=-0.202,P=0.840),HbA1c水平分别为(5.63±0.53)%、(5.50±0.56)%,差异有统计学意义(t=-2.629,P=0.009)。小细胞低色素性贫血、正细胞低色素性贫血、正细胞正色素性贫血3组间进行组内和组间比较发现,3组孕妇FPG水平分别为(5.01±2.30)、(4.65±0.89)、(4.97±1.02)mmol/L,两两之间比较差异无统计学意义(P>0.05),HbA1c水平分别为(5.62±0.55)%、(5.76±0.28)%、(5.50±0.46)%,小细胞低色素性贫血组和正细胞低色素性贫血组孕妇HbA1c水平均高于正细胞正色素性贫血组,差异均有统计学意义(P<0.05)。结论妊娠早期孕妇低色素性贫血对HbA1c水平有明显影响,低色素性贫血可引起妊娠早期孕妇HbA1c水平升高。
Objective To investigate the effect of hypochromatic anemia on glycosylated hemoglobin(HbA1c)level in early pregnancy.Methods From November 2017 to April 2018,a total of 544 pregnant women at 7-12 gestational weeks with normal fasting blood glucose(FPG),including 346 cases with hemoglobin(Hb)≥110 g/L(anemia group),198 cases with Hb<110 g/L(non-anemia group)were retrospectively analyzed.According to mean erythrocyte volume(MCV)and mean erythrocyte hemoglobin(MCH),544 pregnant women were divided into hypochromia group and normochromic group.There were 194 cases in the hypochromia group,including 173 cases of microcytic hypochromic anemia(MCV<82 fL,MCH<27 pg)and 21 cases of normal cell hypochromic anemia(MCV≥82 fL,MCH<27 pg).There were 350 cases in normal cytochrome group(MCV≥82 fL,MCH≥27 pg)including 76 cases of normal cytochrome anemia and 274 cases of normal cytochrome non-anemia.The blood routine,FPG and HbA1c were measured by automatic biochemical analysis and automatic glycosylated hemoglobin analyzer,and the results were compared and analyzed.Results The FPG level of non-anemia group and anemia group was(4.93±0.99)and(4.99±2.16)mmol/L respectively,and the difference was not statistically significant(t=0.409,P=0.683).The levels of HbA1c were(5.53±0.56)%and(5.58±0.55)%,and the difference was not statistically significant(t=-0.960,P=0.338).The FPG levels between hypochromia group(MCH<27 pg)and normochromic group(MCH≥27 pg)were(4.97±2.19)and(4.94±0.98)mmol/L(t=-0.202,P=0.840).The levels of HbA1c were(5.63±0.53)%and(5.50±0.56)%,and the difference was not statistically significant(t=-2.629,P=0.009).The FPG levels among the three groups were(5.01±2.30),(4.65±0.89)and(4.97±1.02)mmol/L,and the differences were not statistically significant(P>0.05).The levels of HbA1c were(5.62±0.55)%,(5.76±0.28)%and(5.50±0.46)%,respectively.The levels of HbA1c in pregnant women with microcytic hypochromic anemia and normal cell hypochromic anemia were higher than that in pregnant women with normal cytochrome anemia,and the differences were statistically significant(P<0.05).Conclusion In the early gestation,hypochromatic anemia has a significant effect on the level of HbA1c,and hypochromatic anemia may cause the increase of level HbA1c in pregnant women in the early pregnancy.
作者
韦松晓
麦莹莹
黎凤元
WEI Songxiao;MAI Yingying;LI Fengyuan(Department of Clinical Laboratory,Wuzhou Red Cross Hospital of Guangxi Zhuang Autonomous Region,Wuzhou,Guangxi 543000,China)
出处
《检验医学与临床》
CAS
2020年第8期1063-1066,共4页
Laboratory Medicine and Clinic
关键词
低色素性贫血
妊娠
血红蛋白
血糖
hypochromic anemia
pregnancy
hemoglobin
blood glucose
