摘要
目的观察前列欣联合多沙唑嗪片治疗老年良性前列腺增生的临床疗效。方法选取2017年1月至2019年1月在兴平市人民医院就诊的老年良性前列腺增生患者157例,按照随机数表法分为观察组78例和对照组79例。对照组采用多沙唑嗪片治疗,观察组在此基础上联用前列欣治疗,均持续用药3个月。比较两组患者的临床疗效,以及治疗前后的临床症状[国际前列腺症状评分(IPSS)、生活质量指数(QoL)、前列腺体积(PV)、残余尿量(RU)、最大尿流率(MFR)]、中医症候和治疗期间的不良反应情况。结果治疗后,观察组和对照组患者的IPSS评分[(9.23±2.68)分vs (11.34±3.02)分]、QoL [(1.81±0.78)分vs (2.31±0.64)分]、RU [(19.24±8.24) mL vs (29.13±9.11) mL]、PV [(35.22±6.13) m L vs (40.05±7.11) m L]比较,观察组明显低于或少于对照组,MFR为(17.12±2.19) m L/s,明显高于对照组的(13.24±1.89) mL/s,差异均有统计学意义(P<0.05);观察组患者的治疗总有效率为94.87%,明显高于对照组的84.81%,差异有统计学意义(P<0.05);两组患者的中医症候各项积分均较治疗前下降,且观察组下降较对照组更明显,差异均有统计学意义(P<0.05);治疗期间,观察组和对照组患者的不良反应率分别为6.41%、11.39%,差异无统计学意义(P>0.05)。结论前列欣联合多沙唑嗪治疗良性前列腺增生较单一多沙唑嗪疗效好,其能有效改善患者临床症状和中医症候,且不会加重不良反应,安全性好。
Objective To observe clinical curative effect of Qianliexin combined with doxazosin tablets on benign prostatic hyperplasia(BPH) in the elderly. Methods A total of 157 elderly BPH patients who were treated in Xingping People’s Hospital during the period from January 2017 to January 2019 were enrolled. They were divided into observation group(78 cases) and control group(79 cases) according to random number table. The patients in the control group were treated with doxazosin tablets, while those in the observation group were additionally treated with Qianliexin. The clinical curative effect, clinical symptoms(International Prostate Symptom Score [IPSS], Quality of Life Index[Qo L], prostate volume [PV], residual urine volume [RU], maximum flow rate [MFR]) before and after treatment, TCM syndromes, and adverse reactions during treatment were compared between the two groups. Results After treatment, IPSS score, Qo L score, RU, and PV in the observation group were significantly lower than those in the control group(P<0.05): IPSS,(9.23 ± 2.68) points vs(11.34 ± 3.02) points;Qo L,(1.81 ± 0.78) points vs(2.31 ± 0.64) points;RU,(19.24 ± 8.24) m L vs(29.13±9.11) mL;PV,(35.22±6.13) m L vs(40.05±7.11) mL. MFR was significantly higher than that in control group(P<0.05):(17.12±2.19) mL/s vs(13.24±1.89) mL/s. The total response rate of treatment in observation group was significantly higher than that in control group(94.87% vs 84.81%, P<0.05). After treatment, scores of TCM symptom in both groups were decreased, and the decrease in the observation group was more significant than that in the control group(P<0.05). There was no significant difference in adverse reaction rate between the two groups during treatment(6.41% vs11.39%, P>0.05). Conclusion The curative effect of Qianliexin combined with doxazosin is better than that of doxazosin on BPH, which can effectively improve clinical symptoms and TCM symptoms, and will not aggravate adverse reactions, with good safety.
作者
许盟康
郝宇雷
刘航
XU Meng-kang;HAO Yu-lei;LIU Hang(Department of Urology,Xingping People's Hospital,Xingping 713100,Shaanxi,CHINA)
出处
《海南医学》
CAS
2020年第7期851-854,共4页
Hainan Medical Journal
关键词
老年
良性前列腺增生
前列欣
多沙唑嗪片
临床疗效
排尿功能
Elderly
Benign prostatic hyperplasia
Qianliexin
Doxazosin tablet
Clinical curative effect
Urinary function
