摘要
开展了2-卤代苯甲酰胺与腈类化合物反应生成喹唑啉-4(3H)-酮类衍生物的微波辅助合成研究。结果表明:在微波辅助条件下,生成的喹唑啉-4(3H)-酮类衍生物的速率均较常规加热条件下增大,并且2-碘代苯甲酰胺比2-溴苯甲酰胺活性更高。一系列的喹唑啉-4(3H)-酮衍生物被高效地合成出来,最高产率达到89%。
Microwave-assisted organic synthesis of quinazolin-4(3H)-ones through the reaction of 2-halobenzamides and nitriles was investigated.The results showed the yield was improved significantly when the reaction was carried out under microwave irradiation.2-Iodobenzamides were more reactive than 2-bromobenzamides with higher yields.A variety of quinazolin-4(3H)-ones could be synthesized in good to excellent yields up to 89%.
作者
李震
刘圣亚
李飞
孔迎春
LI Zhen;LIU Sheng-ya;LI Fei;KONG Ying-Chun(Office of Academic Research,Yunnan Normal University,Kunming 650500,China;Faculty of Graduate Studies,Assumption University,Bangkok 10240,Thailand)
出处
《化学研究与应用》
CAS
CSCD
北大核心
2020年第4期622-626,共5页
Chemical Research and Application
基金
国家自然科学基金项目(21777136)资助
云南省教育厅科学研究基金项目(2015Y108)资助。
