摘要
骨骼肌的生长发育是一个受多种功能性因子调控的精密网络过程,其中MyoD是一种骨骼肌特异性转录因子,能够识别并启动骨骼肌特异基因的转录。非编码RNA是一类具有多种生物功能但不能编码蛋白质的RNA。现就目前与MyoD协同作用,共同参与肌细胞增殖、分化、融合等过程的非编码RNA及其作用机制进行综述,以期为阐明与MyoD相关非编码RNA的作用机制提供理论参考。
The growth and development of skeletal muscle is a precise network process regulated by multiple functional factors. The MyoD is a skeletal muscle-specific transcription factor that recognizes and initiates the transcription of skeletal muscle-specific genes. Non-coding RNA is a type of RNA that has multiple biological functions but cannot encode proteins. In this paper, we summarized the functions and mechanisms of non-coding RNAs involved in the proliferation, differentiation and fusion of myocytes, aiming to provide theoretical references for the mechanisms of MyoD-related non-coding RNAs.
作者
吴怡琦
晋大鹏
秦本源
李文霞
张雪莲
史文倩
蔡春波
高鹏飞
郭晓红
李步高
曹果清
WU Yi-Qi;JIN Da-Peng;QIN Ben-Yuan;LI Wen-Xia;ZHANG Xue-Lian;SHI Wen-Qian;CAI Chun-Bo;GAO Peng-Fei;GUO Xiao-Hong;LI Bu-Gao;CAO Guo-Qing(College of Animal Science and Veterinary Medicine,Shanxi Agricultural University,Taigu 030801,China;Institute of Animal Sciences,Chinese Academy of Agricultural Sciences,Beijing 100193,China)
出处
《生命科学》
CSCD
北大核心
2020年第1期29-37,共9页
Chinese Bulletin of Life Sciences
基金
三晋学者支持计划专项经费资助项目(2016,2017)
山西省1331工程资助(2019)
国家自然科学基金项目(31872336)
山西省农业重点研发项目(201803D221022-1)。
