摘要
自闭症谱系障碍是儿童发育早期出现的一种神经发展性疾病。近年来,基于婴幼儿同胞研究范式的脑神经科学研究发现,自闭症儿童发育早期会出现皮层表面积加速增大、脑脊液异常增加和脑白质结构异常,这些发现有助于追踪自闭症儿童大脑和核心行为症状的发育轨迹,预测自闭症早期的发生和后期的发展趋势。本文对自闭症儿童早期脑结构发育异常及其神经机制的研究进行了系统梳理,以期深入理解自闭症的发病机制,助益于自闭症的早期筛查、靶向干预和有效康复。
Autism Spectrum Disorders(ASD)are a neuro-developmental disease that occurs early in childhood development.Neuroscience research using the infant sibling study paradigm indicated abnormal brain growth,structural abnormalities of white matter and irregular increase of cerebrospinal fluid in the very early development of ASD children.These findings are helpful to track the developmental trajectory of brain and core behavioral symptoms for children with ASD as well as predict the early onset and later developmental trends of ASD.Additionally,the neural mechanism underling the brain structural abnormalities can improve the understanding of pathogenesis of ASD.This paper reviewed the research on the very early abnormal brain structural development and its neural mechanism in ASD,with a view to understanding the pathogenesis of ASD and providing reference for early screening,targeted intervention and effective rehabilitation of ASD.
作者
王琳
王志丹
王畅
WANG Lin;WANG Zhidan;WANG Chang(Faculty of Education,Jiangsu Normal University,Xuzhou,221116)
出处
《中国特殊教育》
CSSCI
北大核心
2020年第3期55-61,共7页
Chinese Journal of Special Education
基金
2018年度江苏省社科基金青年项目“精准扶贫背景下农村自闭症儿童社会学习特征及教育对策研究”(项目批准号:18JYC003)。
关键词
自闭症谱系障碍
儿童早期
脑结构
发育异常
神经机制
Autism Spectrum Disorders
early childhood
brain structure
developing abnormalities
neural mechanism
