摘要
植物多糖作为一种具备多种生物活性的天然产物,因其具备高效、低毒等优势成为食品抗肿瘤领域的研究热点。研究发现,植物多糖应用于抗肿瘤临床实验中,有助于解除免疫抑制,增强免疫应答,抑制肿瘤的生长、侵袭及转移。本文主要概括了近10年来国内外抗肿瘤植物多糖的种类,从直接抗肿瘤作用、调控肿瘤微环境、红细胞免疫、铁代谢4个方面阐述了植物多糖的抗肿瘤作用机制,并讨论了植物多糖抗肿瘤的构效关系,对植物多糖抗肿瘤的研究方向进行展望,以期促进植物多糖的深入研究,为抗肿瘤食品的研发提供理论参考。
As a class of natural products with many biological activities, plant polysaccharides have become a research hotspot in the field of anti-tumor functional foods because of their advantages of high efficiency and low toxicity. Clinical anti-tumor trials have demons plant polysaccharides can alleviate immunosuppression, enhance immune response, and inhibit the growth, invasion and metastasis of tumors. In this review, the anti-tumor plant polysaccharides that have been reported over the decade are summarized. The anti-tumor mechanisms of plant polysaccharides are elucidated from four perspectives: regulation of tumor microenvironment, targeted cancer cell therapy, iron metabolism and erythrocyte immunity. Finally, the structure-activity relationship of anti-tumor plant polysaccharides is also discussed, and future research directions are presented in order to promote in-depth studies of plant polysaccharides and provide a theoretical basis for the research and development of anti-cancer foods.
作者
边亮
陈华国
周欣
BIAN Liang;CHEN Huaguo;ZHOU Xin(Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment,Guizhou Engineering Laboratory for Quality Control&Evaluation Technology of Medicine,Research Center for Quality Control of Natural Medicine,Guizhou Normal University,Guiyang 550001,China)
出处
《食品科学》
EI
CAS
CSCD
北大核心
2020年第7期275-282,共8页
Food Science
基金
国家自然科学基金面上项目(31570358)
贵州省科技计划项目(黔科合支撑[2018]2826)
贵州省高层次创新人才培养项目(黔科合人才(2015)4033号)
贵州省优秀青年科技人才项目(黔科合平台人才[2017]5625)
贵州省普通高等学校科技拔尖人才支持计划项目(黔教合KY字[2017]065)。
关键词
植物多糖
抗肿瘤
作用机制
plant polysaccharides
antitumor
mechanism
