摘要
目的研究子宫动脉栓塞术联合局部化疗对妊娠滋养细胞肿瘤合并大出血患者生育功能及生存质量的影响。方法选取2006年1月-2012年12月在新疆医科大学第一附属医院治疗的妊娠滋养细胞肿瘤合并阴道大出血的患者120例,均紧急行子宫动脉栓塞术,将其随机分为对照组和研究组,各60例。对照组患者在子宫动脉栓塞术后,再进行常规化疗;研究组患者在行子宫动脉栓塞术时,行局部血管灌注化疗药物,之后继续常规化疗。观察两组患者的治疗效果、血液绒毛膜促性腺激素(HCG)、子宫体积、肿瘤大小、生育功能、生命质量的之间的差异。结果研究组治疗效果(96.67%)明显高于对照组(81.67%),研究组肿瘤大小较对照组显著下降(P<0.05);血液HCG和子宫大小的变化差异无统计学意义;研究组患者的生育功能以及生命质量均明显优于对照组患者(P<0.05)。结论子宫动脉栓塞术联合局部化疗可以最大程度保护患者的生育能力,同时对于肿瘤的抑制作用更好,对于患者预后生活质量有着显著提升作用,值得在临床中推广。
Objective To observe the effect of uterine arterial embolization combined with local chemotherapy on the fertility and quality of life of gestational trophoblastic tumor patients with hemorrhoea.MethodsFrom January 2006 to December 2012,a total of 120 cases of gestational trophoblastic tumor with hemorrhoea in the First Affiliated Hospital of Xinjiang Medical University were selected,which divided into control group and study group,respectively 60 cases in each group.All cases underwent regular chemotherapy after uterine artery embolization,but study group also underwent local vascular perfusion chemotherapy during uterine artery embolization.The differences of the two groups on index of treatment effect,blood HCG,uterine volume,tumor size,reproductive function,quality of life were compared.ResultsThe therapy effect of the study group(96.67%)was significantly higher than that of the control group(81.67%),and the tumor size significantly decreased in the study group(P<0.05).There were no significant difference in the blood HCG level and uterine size between the two groups.The reproductive function and quality of life in the study group were better than that in the control group(P<0.05).ConclusionUterine artery embolization combined with local chemotherapy has significantly improved fertility function and quality of life in gestational trophoblastic tumor patients with hemorrhoea,and is worthy of promotion in clinical practice.
作者
赵骏达
梁凌云
殷艳
ZHAO Junda;LIANG Lingyun;YIN Yan(Department of the Gynecology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China;Department of the Obstetrics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China)
出处
《新疆医科大学学报》
CAS
2020年第4期462-465,共4页
Journal of Xinjiang Medical University
基金
新疆维吾尔自治区自然科学基金(2016D01C282)。
关键词
子宫动脉栓塞术
局部化疗
滋养细胞肿瘤
生育功能
生存质量
uterine arterial embolization
local chemotherapy
gestational trophoblastic tumor patients
fertility
quality of life
