摘要
目的观察归芪活血胶囊联合氟哌噻吨美利曲辛治疗脑卒中后抑郁症的临床效果。方法选取2018年9月-2019年3月漳平市总医院收治的因缺血导致的脑卒中后抑郁症患者110例,根据入院先后顺序随机分为观察组和对照组,每组55例。对照组给予氟哌噻吨美利曲辛治疗,观察组在对照组基础上加用归芪活血胶囊治疗。比较2组治疗前后抑郁自评量表(SDS)和焦虑自评量表(SAS)评分,治疗前及治疗4、8周后血清去甲肾上腺素(NE)和5-羟色胺(5-HT)水平,治疗效果。结果治疗8周后,2组SDS、SAS评分均低于治疗前,且观察组低于对照组(P<0.01);治疗后4、8周,2组血清NE、5-HT水平均较治疗前升高,且观察组较对照组升高更显著(P<0.01);治疗8周后,观察组总有效率为92.7%,高于对照组的74.5%(P<0.01)。结论氟哌噻吨美利曲辛联合归芪活血胶囊治疗脑卒中后抑郁症效果较好,可提高患者血清NE、5-HT水平。
Objective To observe the clinical effect of Guiqi Huoxue capsule combined with flupentixol and melitracex in patients with post-stroke depression.Methods A total of 110 post-stroke depression patients who were admitted to our hospital from September 2018 to March 2019 were enrolled.According to the order of admission,they were divided into 55 patients in the control group and the observation group.The patients in the control group were treated with oral flupentixol and melitracen.The patients in the observation group were treated with Guiqi Huoxue capsule on the basis of the control.The treatment was performed for 8 weeks.The two groups were counted before treatment and after 8 weeks.Compare the self-depression scale(SDS)and anxiety scale(SAS)scores were compared with the level and clinical efficacy of NE and serum 5-HT after 4 and 8 weeks of treatment.Results After 8 weeks of treatment,the SDS and SAS scores of the two groups were significantly lower than those before treatment,and the two scores of the observation group were lower than the control group(P<0.01).The serum and NE-HT of the observation group were treated after 4 and 8 weeks.The water level was significantly higher than that of the control group(P<0.01).The total effective rate of the observation group was 92.7%,which was significantly higher than that of the control group(74.5%),and the difference was statistically significant(P<0.01).Conclusion Flupentixol and melitracex combined with Guiqi Huoxue capsule can be used to improve the therapeutic effect of poststroke depression by increasing the levels of NE and 5-HT in the serum of patients.
作者
郑瑞锋
ZHENG Ruifeng(Department of Neurology,Zhangping General Hospital,Fujian Province,Zhangping 364400,China)
出处
《临床合理用药杂志》
2020年第8期9-10,12,共3页
Chinese Journal of Clinical Rational Drug Use
