摘要
目的探讨藤黄健骨胶囊联合玻璃酸钠注射液治疗膝骨关节炎的临床疗效。方法选取2018年7月-2019年6月在郑州市骨科医院就诊的94例膝骨关节炎患者作为研究对象,将所有患者按照随机数字表法分为对照组和治疗组,每组各47例。对照组腔内注射玻璃酸钠注射液,2.0 mL/次,1次/周。治疗组在对照组治疗的基础上口服藤黄健骨胶囊,1.0 g/次,2次/d。两组患者连续治疗5周。观察两组患者临床疗效,同时比较治疗前后两组患者膝关节功能、疼痛程度和血清炎性因子水平。结果治疗组的总有效率为91.49%,对照组的总有效率为76.60%;两组的总有效率比较差异有统计学意义(P<0.05)。治疗后,两组的Lysholm评分高于治疗前,VAS评分明显低于治疗前(P<0.05);在治疗后治疗组的Lysholm评分比对照组高,VAS评分低于对照组,差异有统计学意义(P<0.05)。治疗后,两组的白介素1β(IL-1β)、白介素17(IL-17)、白介素23(IL-23)、胰岛素样生长因子1(IGF-1)水平均明显低于治疗前(P<0.05);在治疗后治疗组的IL-1β、IL-17、IL-23、IGF-1水平均比对照组低,差异有统计学意义(P<0.05)。结论藤黄健骨胶囊联合玻璃酸钠注射液能提高膝骨关节炎的临床疗效,改善关节功能,减轻疼痛,降低血清炎性因子水平,具有一定临床研究价值。
Objective To investigate the clinical effect of Tenghuang Jiangu Capsules combined with Sodium Hyaluronate Injection in treatment of knee osteoarthritis. Methods Patients(94 cases) with knee osteoarthritis in Zhengzhou Orthopedic Hospital from July 2018 to June 2019 were divided into control(47 cases) and treatment(47 cases) groups based on random number table method. Patients in the control group were intraarticular injection of Sodium Hyaluronate Injection, 2.0 mL/time, once weekly. Patients in the treatment group were po administered with Tenghuang Jiangu Capsules on the basis of the control group, 1.0 g/time, twice daily. Patients in two groups were treated for 5 weeks. After treatment, the clinical efficacy was evaluated, and the knee function, degree of pain, and the serum levels of inflammatory factors in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 76.60%, which was significantly lower than91.49% in the treatment group, and there were differences between two groups(P < 0.05). After treatment, Lysholm scores in two groups were significantly increased, but the VAS scores were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the Lysholm scores in the treatment group were significantly higher than those in the control group, but the VAS scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of IL-1β, IL-17, IL-23 and IGF-1 in the two groups were significantly decreased(P < 0.05). And the serum levels of inflammatory factors in the treatment group were significantly lower than those in the control group(P < 0.05). Conclusion Tenghuang Jiangu Capsules combined with Sodium Hyaluronate Injection has clinical curative effect in treatment of knee osteoarthritis, can improve joint function, relieve pain, reduce the level of serum inflammatory factors, which has a certain clinical application value.
作者
司文腾
陈宾
周宇
SI Wen-teng;CHEN Bin;ZHOU Yu(Joint Surgery,Zhengzhou Orthopedic Hospital,Zhengzhou 450052,China)
出处
《现代药物与临床》
CAS
2020年第3期525-528,共4页
Drugs & Clinic
关键词
藤黄健骨胶囊
玻璃酸钠注射液
膝骨关节炎
关节功能
疼痛程度
炎性因子
Tenghuang Jiangu Capsules
Sodium Hyaluronate Injection
knee osteoarthritis
knee function
degree of pain
inflammatory factor
