摘要
目的探讨阿司匹林联合氯吡格雷治疗脑梗死效果。方法将我院2018年1月-2019年1月脑梗死患者100例,随机分组,单纯阿司匹林组脑梗死患者采取单纯阿司匹林治疗,联合药物干预组对于就诊脑梗死患者采取阿司匹林联合氯吡格雷治疗。比较两组脑梗死疗效;治疗前后患者血小板聚集率、NHISS评分、Barthel指数;不良反应发生率。结果联合药物干预组疗效达到90%远高于单纯阿司匹林组76%,χ^2=6.933,P<0.05。两组胃肠道不适等不良反应发生率(4%和6%)差异不显著,χ^2=1.032,P>0.05。联合药物干预组血小板聚集率、NHISS评分、Barthel指数均优于单纯阿司匹林组,P<0.05。两组胃肠道不适等不良反应发生率差异不显著,P>0.05。结论阿司匹林联合氯吡格雷治疗脑梗死效果良好,可降低血小板聚集率,改善神经功能和患者生活能力,未增加并发症。
Objective To investigate the effect of aspirin combined with clopidogrel in the treatment of cerebral infarction.Methods One hundred patients with cerebral infarction from January 2018 to January 2019 in our hospital were randomized.Patients with cerebral infarction in the aspirin group were treated with aspirin alone.The combination drug intervention group was treated with aspirin and clopidogrel for patients with cerebral infarction.The curative effect of cerebral infarction was compared between the two groups;the platelet aggregation rate,NHISS score,Barthel index before and after treatment;the incidence of adverse reactions.Results The efficacy of the combination drug intervention group was 90%,which was much higher than that of the aspirin group alone 76%,χ^2=6.933,P<0.05.The incidence of adverse reactions such as gastrointestinal discomfort(4%and 6%)was not significant,χ^2=1.032,P>0.05.The platelet aggregation rate,NHISS score and Barthel index of the combination drug intervention group were better than those of the simple aspirin group,P<0.05.There was no significant difference in the incidence of adverse reactions such as gastrointestinal discomfort between the two groups,P>0.05.Conclusion Aspirin combined with clopidogrel is effective in treating cerebral infarction,which can reduce platelet aggregation rate,improve neurological function and patient’s living ability,and increase complications.
作者
王伟伟
WANG Weiwei(Department of Neurology,People's Hospital of Lingcheng District,Dezhou City,Dezhou Shandong 253500,China)
出处
《中国卫生标准管理》
2020年第6期90-92,共3页
China Health Standard Management
关键词
阿司匹林
氯吡格雷
脑梗死
效果
生活能力
神经功能
aspirin
clopidogrel
cerebral infarction
effect
life ability
nerve function
