摘要
背景:肾结石发生病因有很多,但对于肾脏解剖形态学研究是否影响结石的产生还未有明确答案。目的:重建肾脏的三维立体模型;测量与肾结石病因的相关解剖结构数据进行分析。方法:随机选取2017年12月至2019年2月在北京房山区良乡医院就诊的30例肾结石患者作为肾结石组,对照组是同期进行体检的正常人30例。两组受试者采集肾脏CT的扫描数据后,利用Mimics 16.0.软件通过图像分割和融合来重建肾脏的三维立体模型;测量肾脏长度、肾脏宽度、肾窦长径、肾窦宽径、肾盂与输尿管连接处直径、肾上缘至棘突纵线距离、肾下缘至棘突纵线距离、肾门至棘突纵线距离;并对肾结石患者肾脏解剖学指标进行多参数Logistics回归分析。结果与结论:①肾结石患者与正常人的肾在肾脏长度、肾脏宽度、肾窦长径、肾窦宽径、肾盂与输尿管连接处直径、肾上缘至棘突纵线距离、肾下缘至棘突纵线距离、肾门至棘突纵线距离方面的三维数字化测量结果差异无统计学意义(P>0.05)。②肾结石患者肾脏解剖学多参数Logistics回归分析结果表明,肾结石患者的肾脏长度、肾脏宽度、肾窦长径、肾窦宽径、肾盂与输尿管连接处直径、肾上缘至棘突纵线距离、肾下缘至棘突纵线距离、肾门至棘突纵线距离等与肾结石的形成无明显相关性(P>0.05)。提示肾脏形态学的不同与结石形成无关。
BACKGROUND:There are many causes of kidney stones,but there is no clear answer to whether kidney anatomy and morphology studies affect the generation of stones.OBJECTIVE:To reconstruct a three-dimensional model of the kidney and to measure and analyze anatomical data related to the etiology of kidney stones.METHODS:Thirty patients with kidney stones treated at Liangxiang Hospital in Fangshan District,Beijing from December 2017 to February 2019 were randomly selected as the study group,and the control group was 30 normal people who underwent physical examination during the same period.After collecting renal CT scan data from two groups of patients,the three-dimensional model of the kidney was reconstructed by image segmentation and fusion using Mimics 16.0.The length and width of the kidney,the length and width of the renal sinus,diameter of the junction between the renal pelvis and ureter,the distance from the upper edge of the kidney to the longitudinal line of the spinous process,the distance from the lower edge of the kidney to the longitudinal line of the spinous process,and the distance from the hilum to the longitudinal line of the spinous process.Multi-parameter Logistic regression analysis was performed on kidney anatomy parameters of patients with kidney stones.RESULTS AND CONCLUSION:There were no significant differences in the three-dimensional digital measurement results between patients with kidney stones and healthy people in the following aspects:the length and width of the kidney,length and width of the renal sinus,diameter of the junction between the renal pelvis and ureter,distance from the upper edge of the kidney to the longitudinal line of the spinous process,distance from the lower edge of the kidney to the longitudinal line of the spinous process,and distance from the hilum to the longitudinal line of the spinous process(P>0.05).Multi-parameter Logistic regression analysis results of the kidney of patients with kidney stones indicated that there was no significant correlation among the length and width of the kidney,length and width of the renal sinus,diameter of the junction between the renal pelvis and ureter,distance from the upper edge of the kidney to the longitudinal line of the spinous process,distance from the lower edge of the kidney to the longitudinal line of the spinous process,and distance from the hilum to the longitudinal line of the spinous process(P>0.05).These findings reveal that the difference in kidney morphology has nothing to do with the formation of stones.
作者
武利兵
许阳阳
和雨洁
王海燕
高尚
恩和吉日嘎拉
李筱贺
李志军
Wu Libing;Xu Yangyang;He Yujie;Wang Haiyan;Gao Shang;Enhejirigala;Li Xiaohe;Li Zhijun(Department of Urinary Surgery,Liangxiang Hospital in Fangshan District,Beijing 102446,China;Department of Anatomy,Basic Medical College,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Graduate School,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China)
出处
《中国组织工程研究》
CAS
北大核心
2020年第29期4662-4666,共5页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金(81460330),项目负责人:李筱贺
国家自然科学基金(81560348,81860383),项目负责人:李志军
内蒙古教育厅青年科技英才项目(njyt-15-b05),项目负责人:李筱贺
内蒙古自治区科技计划项目(2016),项目负责人:李筱贺
内蒙古自治区科技计划项目(2019),项目负责人:李志军
内蒙古自治区科技创新引导项目(2017),项目负责人:李筱贺
内蒙古自治区自然科学基金(2016ms08131)
内蒙古人社厅归国留学人员基金(TKD2017KJBW012),项目负责人:李筱贺
内蒙古医科大学科技百万计划基金项目(YKD2017KJBW012),项目负责人:王海燕。
关键词
肾结石
数字化测量
三维重建
解剖学病因
kidney stones
digital measurement
three-dimensional reconstruction
anatomical etiology
