摘要
目的 探讨甲状腺功能减退症(甲减)患者代谢特征变化趋势.方法 选择2018—2019年溧阳市中医医院内分泌科收治的新诊断的甲减患者93例,包括临床甲减患者32例和亚临床甲减患者61例;另选甲状腺健康者50例作为对照组.比较临床甲减组、亚临床甲减组和对照组甲状腺功能、血脂、尿酸和血糖水平.然后依据甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPoAb)结果将入组的93例甲减患者分为抗体阳性组和阴性组,进一步对两组患者的上述指标进行比较.结果 临床甲减组、亚临床甲减组和对照组促甲状腺激素(TSH)、三碘甲状腺原氨酸(FT3)和游离甲状腺素(FT4)、甘油三酯(TG)、尿酸(SUA)、空腹血糖(FBG)水平差异有统计学意义(P<0.05);而TC、LDL水平差异无统计学意义(P>0.05).甲状腺相关抗体阳性组和阴性组TSH、FT3、FT4、TG、SUA水平差异有统计学意义(P<0.05);而TC、LDL、FBG水平差异无统计学意义(P>0.05).结论 甲减患者SUA、TG及FBG水平高于健康人;尤其是其中甲状腺相关抗体阳性患者,SUA、TG水平进一步升高,更易于出现代谢综合征.
Objective To explore the metabolic characteristics of hypothyroidism(hypothyroidism).Methods A total of 93 newly diagnosed hypothyroidism patients,including 32 clinical hypothyroidism patients and 61 subclinical hypothyroidism patients,were selected from the endocrine department of Liyang Hospital of traditional Chinese medicine from 2018 to 2019.and 50 healthy were selected as the control group.The thyroid function,blood lipid,uric acid and blood glucose levels were compared among the clinical hypothyroidism group,the subclinical hypothyroidism group and the control group.Then,according to the results of TgAb and TPOAb.93 hypothyroidism patients were divided into antibody positive group and antibody negative group,and the above indexes were compared between the two groups.Results The levels of TSH.FT,.FT4,TG.SUA and FBG in clinical hypothyroidism group,subclinical hypothyroidism group and control group were significantly different(P><0.05).but the levels of TC and LDL were not significantly different(P>O.05).There were significant differences in TSH.FT3.FT44,TG and SUA levels between the thyroid related antibody positive and negative groups(P<0.05).but no significant differences in TC,LDL and FBG levels(P>O.05).Conclusion The levels of SUA,TG and FBG in hypothyroidism patients arc higher than those in healthy people,and the levels of SUA and TG are further increased in thyroid related antibody positive patients,which is more prone to metabolic syndrome.
作者
陈燕霞
CHEN Yanxia(Department of Endocrinology,Liyang Hospital of traditional Chinese medicine,Liyang 213300,Jiangsu Province,China)
出处
《中国实用乡村医生杂志》
2020年第4期67-69,共3页
Chinese Practical Journal of Rural Doctor
