摘要
探讨海藻多糖可溶性粉对靶动物猪的安全性评价,为临床应用提供科学依据。将50头仔猪随机分为空白对照组和4个试验剂量组,试验剂量组分别按照海藻多糖临床推荐剂量(200 mg/kg饲料)的1、3、5、10倍量给药,连续给药7 d,于试验前和试验结束后分别称量试验猪体重,并在给药第7天和第14天采血进行血常规和血液生化指标检测。结果显示,与空白对照组相比,海藻多糖可溶性粉1、3倍剂量组均可显著提高仔猪体重(P<0.05)。用药第7天和第14天后,虽然海藻多糖可溶性粉试验剂量组血常规和血液生化结果与空白对照组相比以及组间比较时,或有显著的升高与降低,但均在猪血液生理生化指标的正常范围之内。除此之外,各试验组仔猪精神状态良好、饮食正常,无不良症状出现。表明海藻多糖可溶性粉在临床推荐剂量的1倍~10倍内使用,未出现毒性反应,对靶动物猪是安全的。
This paper aimed to investigate the safety of seaweed polysaccharide soluble powder in target animals(swine)and provide a basis for clinical application.Fifty piglets were randomly divided into a blank control group and four test dose groups.The test dose groups were administered at 1,3,5,and 10 times of the clinically recommended dose of seaweed polysaccharide(200 mg/kg feed)for 7 consecutive days.The animals were weighed before and after treatments,and blood was taken for blood routine and biochemical tests on the 7th and 14th day of administration.The results showed that,compared with the blank control group,the weight of piglets was significantly increased in seaweed polysaccharide soluble powder 1 and 3 times dose groups(P<0.05).After the 7th day and the 14th day of treatment,there were some dynamic changes in the blood routine examination and blood biochemical indexes between experimental groups and control group,but both were within the normal ranges of blood physiological and biochemical indicators.In addition,the piglets in each test group had good mental state,normal diet,and no adverse symptoms.The results showed that if the seaweed polysaccharide soluble powder is used at dose from 1 to 10 times of the clinically recommended dose,no toxic symptoms will occur and it is safe for swine.
作者
安慧青
肖蕊
刘倩
宋漫玲
韦秀颖
吴苑滢
谢小东
施君
韦英益
胡庭俊
AN Hui-qing;XIAO Rui;LIU Qian;SONG Man-ling;WEI Xiu-ying;WU Yuan-ying;XIE Xiao-dong;SHI Jun;WEI Ying-yi;HU Ting-jun(College of Animal Science and Technology,Guangxi University,Nanning,Guangxi,530005,China)
出处
《动物医学进展》
北大核心
2020年第4期77-81,共5页
Progress In Veterinary Medicine
基金
国家自然科学基金项目(31260619)
南宁市科学研究与技术开发计划项目(20175031-4)。
关键词
海藻多糖
可溶性粉
靶动物
猪
安全性
seaweed polysaccharide
soluble powder
piglet
safety
