摘要
目的探讨血清肿瘤标志物AFP和PIVKA-Ⅱ单独或联合检测在肝癌诊断中的临床意义。方法采用化学发光法分别对61例肝癌患者、30例肝硬化患者、33例其他肝病患者及40例健康体检者(正常对照组)的血清AFP和PIVKA-Ⅱ进行检测,并比较各组水平差异,用ROC曲线评价AFP和PIVKA-Ⅱ诊断肝癌的敏感度、特异度,从而明确AFP和PIVKA-Ⅱ在肝癌中的诊断价值。结果肝癌患者血清中AFP和PIVKA-Ⅱ水平均显著高于肝硬化、其他肝病组和正常组,差异具有统计学意义(P<0.01)。单独检测诊断肝癌时,AFP检测的敏感度高于PIVKA-Ⅱ,为91.8%,而PIVKA-Ⅱ检测的特异度高于AFP,为94.17%。联合检测时可提高敏感度,诊断肝癌的敏感度提高为95.08%。结论联合检测AFP和PIVKA-Ⅱ能提高肝癌的诊断敏感性,避免临床漏诊肝癌的发生。
Objective To explore the clinical diagnosis signifi cance of single or combined testing the levels of serum AFP and PIVKA-Ⅱin liver cancer.Methods A total of 61 patients with liver cancer,30 patients with cirrhosis of liver,33 patients with other liver diseases and 40 healthy subjects(healthy control group)were enrolled.Their serum AFP and PIVKA-Ⅱlevels were determined by chemiluminescence.The difference was compared with each other.The sensitivity and specifi city of the AFP and PIVKA-Ⅱfor the diagnosis of liver cancer were analyzed by ROC Curve.The clinical diagnosis valu e of AFP and PIVKA-Ⅱin liver cancer was evaluated.Results The serum AFP and PIVKA-Ⅱlevel in the liver cancer group was signifi cantly higher than that in the cirrhosis of liver grou p,in the other liver diseases group and in the healthy control group,the differences was statically signifi cant(P<0.01).The sensitivity(91.8%)of AFP single detection were signifi cantly higher than PIVKA-Ⅱfor diagnosis of liver cancer,The specifi city(94.17%)of PIVKA-Ⅱsingle detection were signifi cantly higher than AFP for diagnosis of liver cancer.The sensitivity(95.08%)increased in the clinical diagnosis of the liver cancer by using AFP and PIVKA-Ⅱcombined detection.Conclusion AFP and PIVKA-Ⅱcombined detection can increase the sensitivity in the liver cancer clinical diagnosis and refrain from the missed diagnosis of the liver cancer.
作者
胡仁智
申波
周颖
郭广波
曾莉
孙伟
HU Ren-zhi;SHEN Bo;ZHOU Ying;GUO Guang-bo;ZENG Li;SUN Wei(Department of Clinical Laboratory,Chongqing Traditional Chinese Medicine Hospital,Chongqing 400021,China;Medical Records Room,Chongqing Traditional Chinese Medicine Hospital,Chongqing 400021)
出处
《中国医药指南》
2020年第11期40-42,共3页
Guide of China Medicine
基金
重庆市科委基础科学与前沿技术研究项目(cstc2016jcyjA0194)。
关键词
肝癌
拮抗剂-Ⅱ诱导产生的蛋白
甲胎蛋白
Liver cancer
Protein induced by vitamin K absence or antagonist-Ⅱ
Alph a-fetoprotein
