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不同孕期碘营养水平对甲状腺功能激素的影响 被引量:13

The effect of iodine nutrient level during different time of pregnancy on the thyroid function
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摘要 目的:探讨孕早、中、晚期妇女不同碘营养水平对甲状腺功能激素水平影响。方法:选取2018年5月-2019年2月本院产科门诊孕妇210例为研究对象,孕早、中、晚期分别为72例、70例、68例,检测所有孕妇的尿碘、血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)和游离甲状腺素(FT4)并比较分析。结果:孕早期组碘缺乏率(38.9%)高于孕中期和孕晚期组(P<0.05);孕早、中期妇女甲状腺功能异常主要表现为低FT4血症和亚临床甲状腺功能减退症,极少数孕晚期孕妇存在甲亢;孕早期碘缺乏妇女甲状腺功能异常率(66.7%)高于孕中和孕晚期妇女(P<0.05);孕晚期碘过量妇女甲状腺功能异常率(30.0%)高于孕早期和孕中期组(P<0.05)。结论:妊娠中、晚孕妇碘营养基本处于适宜水平,但孕早期妇女普遍存在碘缺乏。应密切监测妊娠期妇女,特别是孕早期妇女的碘营养水平,对尿碘<150μg/L或>250μg/L的孕妇均应给与甲状腺功能筛查。 Objective:To investigate the effect of different iodine nutrient level of pregnant women during the first,second or third trimesters of pregnancy on their thyroid function and thyroid hormone levels.Method:210 pregnant women were selected in this study from May 2018 to February 2019,which included 72 women in group A(during the first trimesters of pregnancy),70 women in group B(during the second trimesters of pregnancy)and 68 women in group C(during the third trimesters of pregnancy).The levels of urine iodine,serum thyroid stimulating hormone(TSH),free triiodothyronine(FT3),and free thyroxine(FT4)of women were detected and compared among the three groups.Results:The rate of iodine deficiency of women in group A was 38.9%,which was significant higher than those of women in group B and C(P<0.05).Thyroid dysfunction of women in group A and B was mainly manifested as hypoFT4 and subclinical hypothyroidism,and the hyperthyroidism might exist in a few women in group C.The thyroid dysfunction rate of women with iodine deficiency in group A was 66.7%,which was significant higher than that of women in group B or C(P<0.05).The incidence of thyroid dysfunction of women with iodine overdose in group C was 30.0%,which was significant higher than that of women in group A or B(P<0.05).Conclusion:Iodine nutrition level of pregnant women during the second or third trimesters of pregnancy is basically appropriate,but iodine deficiency is still prevalent during the first pregnancy.The iodine nutritional level of pregnant women,especially those women during the first of pregnancy,should be closely monitored.If the pregnant women with urinary iodine<150 ug/L or>250 ug/L,their thyroid function should be screened.
作者 方静 方自国 FANG Jing;FANG Ziguo(The Second People's Hospital of Anqing, Anhui Province, 246004)
出处 《中国计划生育学杂志》 2020年第4期576-579,共4页 Chinese Journal of Family Planning
关键词 妊娠期 碘营养 甲状腺功能 甲状腺激素 Pregnancy Iodine nutrition Thyroid function Thyroid hormone
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