摘要
目的:探讨妊娠期糖尿病(GDM)患者血清血管内皮细胞黏附分子-1(sVCAM-1)、白三烯B4(LTB4)水平与糖脂代谢指标关系。方法:选择2016年9月-2019年2月本院收治的GDM患者135例为观察组,同期正常产前检查孕妇100例为对照组,检测血清sVCAM-1、LTB4水平,血脂代谢指标(胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、血糖代谢指标空腹血糖(PFG)、糖化血红蛋白(HbAlc)、胰岛素抵抗指数(HOMA-RI)),分析血清sVCAM-1、LTB4水平与糖脂代谢指标相关性。结果:观察组血清sVCAM-1(789.56±53.94μg/L)、LTB4水平(865.29±69.53ng/L)高于对照组(423.51±32.65μg/L、352.10±21.60ng/L)(P<0.05)。血清sVCAM-1水平与TG、FPG、HOMA-IR呈正相关(r=0.285,-0.319,P<0.05),与HDL-C呈负相关(r=-0.464,P<0.05);血清LTB4水平与TG、FPG、HbAlc、HOMA-IR呈正相关(r=0.267,-0.495,P<0.05),与HDL-C呈负相关(r=-0.338,P<0.05)。结论:GDM患者血清sVCAM-1、LTB4水平升高,且与糖脂代谢指标密切相关,sVCAM-1、LTB4可能作为GDM糖脂代谢病情变化的监测指标。
Objective:To investigate the relationship between serum vascular endothelial cell adhesion molecule-1(sVCAM-1)and leukotriene B4(LTB4)levels of pregnant women with gestational diabetes mellitus(GDM)and their glucolipid metabolism disorders.Methods:135 pregnant women with GDM were selected in study group from September 2016 to February 2019,and 100 normal women were included in control group during the same period.The serum levels of sVCAM-1 and LTB4,lipid metabolism indicators cholesterol(TC),triglyceride(TG),high-density lipids.Protein(HDL-C),low-density lipoprotein(LDL-C),blood glucose metabolism index fasting blood glucose(PFG),glycosylated hemoglobin(HbAlc),and insulin resistance index(HOMA-RI)of women in the two groups were detected.The correlation between serum sVCAM-1 and LTB4 levels and glucolipid metabolism level was analyzed.Results:The serum levels of sVCAM-1 and LTB4 of women in the observation group were 789.56±53.94μg/L and 865.29±69.53ng/L,which were significant higher than those(423.51±32.65μg/L and 352.10±21.60 ng/L)of women in the control group(P<0.05).The serum sVCAM-1 level was positively correlated with TG and FPG levels,and HOMA-IR value(r=0.285-0.319,P<0.05),and which was negatively correlated with HDL-C level(r=-0.464,P<0.05).The serum LTB4 level was positively correlated with levels of TG,FPG and HbAlc,and HOMA-IR value(r=0.267,-0.495,P<0.05),and which was negatively correlated with HDL-C level(r=-0.338,P<0.05).Conclusion:The serum levels of sVCAM-1 and LTB4 of women with GDM increase significantly,which were closely related to the glycolipid metabolism index.So SVCAM-1 and LTB4 levels can be used as the indexes for monitoring the changes of glycolipid metabolism of women with GDM.
作者
徐燕
王晓庆
XU Yan;Wang Xiaoqing(High-tech Zone People's Hospital of Suzhou, Jiangsu Province, 215000)
出处
《中国计划生育学杂志》
2020年第3期416-419,共4页
Chinese Journal of Family Planning
关键词
妊娠期糖尿病
血管内皮细胞黏附分子-1
白三烯B4
糖脂代谢
Gestational diabetes
Serum vascular endothelial cell adhesion molecule-1
Leukotriene B4
Glycolipid metabolism
