摘要
目的:通过比较自体表皮移植术联合他克莫司和传统自体表皮移植术治疗白癜风的疗效,明确他克莫司乳膏对白癜风复色率的影响。方法:回顾性分析自体表皮移植术联合他克莫司和传统自体表皮移植术治疗的稳定期白癜风患者共90例,比较其均匀复色时间和疗效。结果:表皮移植术联合他克莫司组起效时间显著性短于单一表皮移植术组(P<0.05),1月、3月的显效率和痊愈率均明显高于单一表皮移植术组(P<0.05)。单一表皮移植术组颈部的疗效相比于头面部、躯干部、四肢更佳(P<0.05),表皮移植术联合0.1%他克莫司软膏外用治疗(相对于单一表皮移植术)可显著性提高位于四肢的皮损的疗效(P<0.05)。相较于单一表皮移植术而言,表皮移植术联合他克莫司对提高节段型和局限型白癜风疗效显著(P<0.05)。然而,他克莫司联合治疗可提高散发型和肢端型白癜风的疗效,但无统计学意义(P>0.05)。表皮移植术联合他克莫司组和单一表皮移植术组中,男性疗效均高于女性,但无显著性差异(P>0.05)。结论:自体表皮移植术联合0.1%他克莫司软膏治疗白癜风的疗效优于单一自体表皮移植术,他克莫司可有效提高白癜风复色。
Objective:To compare the efficacy of autologous epidermal grafting combined with tacrolimus and conventional autologous epidermal grafting for vitiligo.Methods:The repigmentation time and efficacy of autologous epidermal grafting combined with tacrolimus group and traditional autologous epidermal grafting in total 90 stable vitiligo patients were retrospectively studied.Results:The epidermal transplantation combined with tacrolimus group had significantly shorter repigmentation time than the single epidermal graft group(P<0.05).The efficacy in the epidermal grafting combined with tacrolimus showed significantly higher at 1 month and 3 months after treatment than that of the single epidermal graft group(P<0.05).The efficacy in different sites are varying,of which the neck is the best;the limbs are the worst.The combination therapy of tacrolimus and autologous epidermal grafting can improve the repigmentation at the site of limbs.The efficacy of autologous epidermal grafting combined with tacrolimus was significantly higher in segmental and localized vitiligo compared with those in single autologous epidermal grafting(P<0.05).However,tacrolimus combination therapy can improve the efficacy of sporadic and acral vitiligo with no statistical difference(P>0.05).There was no significant difference in the gender between the two groups(P>0.05).In autologous epidermal grafting group combined with tacrolimus group and the single epidermal graft group,the efficacy in male was higher than that in female with no significant difference.Conclusion:Autologous epidermal grafting combined with tacrolimus is better for repigmentation than conventional autologous epidermal grafting.
作者
卢宏俐
胡倩倩
何华萍
康俞莉
张立
LU Hong-li;HU Qian-qian;HE Hua-ping;KANG Yu-li;ZHANG Li(Department of Dermatology,Huashan Hospital,Fudan University,Shanghai,200030,China;Department of Nursing,Huashan Hospital,Fudan University,Shanghai,200030,China;Shanghai Institute of Dermatology,Shanghai,200030,China)
出处
《现代生物医学进展》
CAS
2020年第2期273-276,298,共5页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81803159)。
关键词
白癜风
自体表皮移植术
他克莫司
复色
Vitiligo
Autologous epidermal grafting
Tacrolimus
Repigmentation
