摘要
目的:分析细胞治疗的发展特点及临床热点。方法:以2015-2019年间有关细胞治疗的论文、专利、临床试验与技术交易数据为研究对象,采用文献计量方法与可视化技术,利用统计、科学知识图谱与专利地图分析工具,分析细胞治疗领域的科技产出数量及增长趋势、研究机构地理分布、基础研究与应用研究热点主题、重点药物、重大疾病及关键技术。结果:细胞治疗临床热点主要包括嵌合抗原受体(Chimeric Antigen Receptor,CAR)T细胞免疫治疗、干细胞治疗、细胞移植、混合嵌合体、外周血单个核细胞(Peripheral Blood Mononuclear Cell,PBMC)、骨髓瘤、血液肿瘤及癌症等主题。结论:作为一种新的治疗技术,细胞治疗基础研究已处于成熟期,应用研究与临床研究还在发展期,尚未进入大规模临床治疗阶段。我国细胞治疗基础研究处于国际前沿,但应用研究和临床研究与世界先进水平还有一定差距,临床转化水平亟待加强。
Objective To analyze the developmental characteristics of and clinical hotspots in papers on cell therapy.Methods The number of scientific outputs on cell therapy and its increasing trend,distribution of its research institutions,hotspots in its basic and application researches,major drugs used in cell therapy,major diseases and their key treatment technologies were analyzed by bibliometric analysis and visualized technological analysis using statistical analysis,scientific knowledge map analysis and patent map analysis tools with the papers,patents,clinical trials and technology dealing data in 2015-2019 as its research subject. Results Chimetric antigen receptor( CAR)-T cell immunotherapy, stem cell therapy, cell transplantation,CAR,peripheral blood mononuclear cells( PBMC),myeloma,tumor,and cancer were the clinical hotspots in papers on cell therapy. Conclusion As a novel medical technology,the basic research in cell therapy has come into its mature stage while its application research and clinical research remain at its development stage and has not enter into its large scale clinical treatment stage. The basic research in domestic cell therapy finds itself at the international frontier. However,a certain gap is existed in its application and clinical research between China and developed countries.
作者
李玲琍
刘鳗蝶
胡正银
覃筱楚
LI Ling-li;LIU Man-die;HU Zheng-yin;QIN Xiao-chu(Department of hematology,Sichuan University West China Hospital,Chengdu 610041,Sichuan Province,China;Sichuan University West China Nursing School,Chengdu 610041,Sichuan Province,China;Sichuan University Public Administration School,Chengdu 610065,Sichuan Province,China;Chengdu Literature and Information Center,Chinese Academy of Sciences,Chengdu 610041,Sichuan Province,China;Information Center,Guangzhou Institute of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou 510530,Guangdong Province,China)
出处
《中华医学图书情报杂志》
CAS
2020年第1期42-48,共7页
Chinese Journal of Medical Library and Information Science
基金
国家重点研发计划“现代服务业共性关键技术研发及应用示范”专项“珠三角城市群综合科技服务平台研发与应用示范”(课题五)“珠三角城市群典型产业综合科技服务应用示范”(2018YFB1404205)的研究成果。
