摘要
目的探究冠心病不稳定型心绞痛合并冠脉狭窄患者C反应蛋白(CRP)、血管生成素样蛋白2(Angptls 2)、C1q TNF相关蛋白1(CTRP1)的水平变化及其临床意义。方法将西安国际医学中心医院心脏内科2018年2月至2019年2月间收治的53例冠心病不稳定型心绞痛合并冠脉狭窄患者作为观察组,同时选取同一时期入院体检的健康人群53例作为对照组,比较两组受检者的CRP、Angptls 2及CTRP1水平,以及不同冠脉病变支数患者的CRP、Angptls 2及CTRP1水平,并分析CRP、Angptls 2及CTRP1联合检测对患者的临床诊断价值。结果观察组和对照组患者的血清CRP[(5.35±1.83)mg/L vs(0.89±0.28)mg/L]、Angptls 2[(2.68±0.76)μg/L vs(0.91±0.24)μg/L]及CTRP1[(15.96±5.02)ng/mL vs(9.24±2.98)ng/mL]水平比较,观察组明显高于对照组,差异均有统计学意义(P<0.05);冠脉单支狭窄患者血清CRP水平、Angptls 2水平、CTRP1水平为(4.25±1.55)mg/L、(1.47±0.35)μg/L、(13.18±4.02)ng/mL,明显低于多支狭窄患者的(6.48±1.98)mg/L、(3.15±0.97)μg/L、(19.15±5.25)ng/mL,差异均有统计学意义(P<0.05);CRP、Angptls 2及CTRP1检测结果显示,三者联合检测准确率明显高于CRP+Angptls 2、CRP+CTRP1以及CTRP1+Angptls 2两者联合检测,差异均有统计学意义(P<0.05)。结论冠心病不稳定心绞痛合并冠脉狭窄患者CRP、Angptls 2及CTRP1水平明显升高,且多支狭窄患者CRP、Angptls 2及CTRP1水平明显高于单支狭窄患者,三项指标联合检测对患者临床诊断具有重要指导意义。
Objective To explore the clinical levels of C-reaction protein(CRP),angiopoietin-like protein 2(Angptls 2),C1q TNF-related protein 1(CTRP1)in patients with unstable angina pectoris and coronary artery stenosis and its diagnostic value,to provide reference for the treatment of patients.Methods A total of 53 patients with unstable angina pectoris complicated with coronary artery disease,who admitted to Department of Cardiology of Xi’an International Medical Center Hospital from February 2018 to February 2019 were selected as the observation group,and 53 healthy people during the same period were enrolled into the control group.The CRP,Angptls 2 and CTRP1 levels of the two groups of subjects,and the levels of CRP,Angptls 2 and CTRP1 in patients with different coronary artery disease counts were compared,and the clinical diagnostic value of CRP,Angptls 2 and CTRP1 were analyzed.Results The serum CRP,Angptls 2,and CTRP1 in the observation group were(5.35±1.83)mg/L,(2.68±0.76)μg/L,(15.96±5.02)ng/m L,respectively,which were significantly higher than corresponding(0.89±0.28)mg/L,(0.91±0.24)μg/L,(9.24±2.98)ng/m L in the control group(all P<0.05);the serum CRP,Angptls 2,and CTRP1 in patients with single coronary stenosis were(4.25±1.55)mg/L,(1.47±0.35)μg/L,(13.18±4.02)ng/mL,respectively,which were significantly lower than corresponding(6.48±1.98)mg/L,(3.15±0.97)μg/L,(19.15±5.25)ng/mL in patients with multiple stenosis(all P<0.05);compared with CRP plus Angptls 2,CRP plus CTRP1 and CTRP1 plus Angptls 2,the accuracy of the combined detection of CRP,Angptls 2 and CTRP1 test results was significantly higher(P<0.05).Conclusion The levels of CRP,Angptls 2 and CTRP1 in patients with coronary heart disease complicated with unstable angina pectoris were significantly increased,and the levels of CRP,Angptls 2 and CTRP1 in patients with multiple stenosis were significantly higher than those in patients with single stenosis.The combined detection of three indicators for clinical diagnosis has important guiding significance.
作者
贾磊
高钊
JIA Lei;GAO Zhao(Department of Cardiology,Xi'an International Medical Center Hospital,Xi'an 710100,Shaanxi,CHINA)
出处
《海南医学》
CAS
2020年第8期966-968,共3页
Hainan Medical Journal
关键词
冠心病
心绞痛
C反应蛋白
血管生成素样蛋白2
C1qTNF相关蛋白1
诊断
Coronary heart disease
Angina pectoris
C-reactive protein(CRP)
Angiopoietin-like protein 2(Angptls 2)
C1q TNF-related protein 1(CTRP1)
Diagnosis
