摘要
目的:探讨老年女性患者外周血中性粒细胞/淋巴细胞比值(NLR)与原发性骨质疏松(POP)的关系。方法:收集2015年12月至2019年4月在重庆三峡中心医院健康体检≥65岁女性788例为研究对象,按照骨量状况分为三组,其中骨量减少组242例,骨量正常组206例,骨质疏松组340例。分别记录身高、体质量、左侧股骨颈骨密度(BMD)及T-值、体质量指数(BMI)、NLR、亚洲骨质疏松自我评估工具(OSTA)值及血常规、生化等指标。采用SPSS 22.0统计软件分析各指标在三组之间的差异性。采用相关性检验NLR及OSTA与T-值的相关性。采用多因素回归分析骨质疏松的独立影响因素,采用ROC曲线判断NLR、OSTA对诊断OP的价值。结果:骨量减少组、骨量正常组及骨质疏松组的年龄(中位值依次为:66岁、68岁和70岁,χ^ 2=71.596, P<0.001)、BMI(中位数依次为:23.46、24.04和25.41,χ 2=64.936, P<0.001)及NLR(中位数依次为:1.97、2.43和2.84,χ^ 2=106.218, P<0.001)差异有统计学意义;NLR及OSTA均与左侧股骨颈的T-值存在一定的相关性( r=-0.311、0.227,均 P<0.001);多因素回归分析表明年龄、BMI及NLR均是骨质疏松的独立影响因素。NLR诊断骨质疏松的临界值为2.395,最大Youden指数为0.299,敏感度为70.3%,特异度为59.6%;OSTA诊断骨质疏松的临界值为-1.315,最大Youden指数为0.174,敏感性为73.6%,特异性为43.5%。 结论:NLR在筛查老年女性POP方面具有中度敏感度及特异度,值得进一步研究。
Objective To explore the association of peripheral blood neutrophil lymphocyte ratio(NLR)with primary osteoporosis(POP)in Chinese elderly women.Methods From December 2015 to April 2019,a total of 788 elderly women in Chongqing Three Gorges Central Hospital were included in this study.They were divided into three groups according to bone mineral density:242 cases of osteopenia,206 cases of normal bone mineral density and 340 cases of osteoporosis.Their height,weight,statuses of bone of left femoral neck and results of blood tests were recorded,and the values of BMI,NLR and OSTA were calculated.The SPSS statistics software was used to analyze the differences of parameters among the three groups.Logistic regression analysis was used to get significant independent related factors for osteoporosis.The relationship of NLR and OSTA with T-score of left femoral neck was confirmed by Pearson correlation test.ROC curves were used to define the values of NLR and OSTA in diagnosis of osteoporosis.Results There were statistically significant differences in age(median values:66,68 and 70,χ^2=71.596,P<0.001),BMI(median values:23.46,24.04 and 25.415,χ^2=64.936,P<0.001)and NLR(median values:1.97,2.435 and 2.84,χ^2=106.218,P<0.001)among the three groups(all P<0.01).Logistic regression analysis demonstrated that age,BMI and NLR were all independent significant related factors.There was correlation of NLR,OSTA with T-score of left femoral neck.In diagnosis of osteoporosis,the cut-off value,maximum Youden index,sensitivity and specificity were 2.395,0.299,70.3%,59.6%for NLR,and-1.315,0.174,73.6%,43.5%for OSTA.Conclusion NLR has intermediate sensitivity and specificity in screening POP in Chinese elderly women,and deserves future researches.
作者
秦艳兰
徐立新
彭东
王怡
李纯芬
周焱琳
陈田
张鹏
唐程敬
夏娟
李彦
Qin Yanlan;Xu Lixin;Peng Dong;Wang Yi;Li Chunfen;Zhou Yanlin;Chen Tian;Zhang Peng;Tang Chengjing;Xia Juan;Li Yan(Department of Health Management Center,Chongqing Three Gorges Central Hospital,Chongqing,404000,China;Department of Nuclear Medicine,Chongqing Three Gorges Central Hospital,Chongqing,404000,China;Department of Endocrinology,Chongqing Three Gorges Central Hospital,Chongqing,404000,China)
出处
《中国基层医药》
CAS
2020年第6期708-713,共6页
Chinese Journal of Primary Medicine and Pharmacy
基金
重庆市卫生和计划生育科研项目(2016MSXM115)。
