摘要
目的探讨普萘洛尔联合甲巯咪唑辅助治疗甲亢患者的临床疗效。方法选取该院内分泌外科2018年4月至2019年4月收治的56例甲亢患者作为研究对象,根据随机数字表法分为对照组(n=28例)和观察组(n=28例)。对照组患者予以甲巯咪唑治疗,观察组在甲巯咪唑基础上联合普萘洛尔治疗。两组患者均治疗3个月,比较两组患者治疗总有效率、血清甲状旁腺激素水平、骨代谢指标水平变化及不良反应发生情况。结果两组患者治疗3个月后,观察组患者总有效率(92.86%)较对照组治疗总有效率(71.43%)高(P<0.05);治疗后两组患者血清甲状旁腺激素水平高于治疗前,且观察组患者血清甲状旁腺激素水平(24.53±2.33)pg/mL较对照组(19.23±2.01)pg/mL明显(P<0.05);两组患者治疗后骨代谢指标(血钙及骨钙素水平)下降,且观察组患者上述指标下降程度较对照组明显(P<0.05);观察组治疗期间总不良反应发生率(10.71%)较对照组(35.71%)低,差异具有统计学意义(P<0.05)。结论普萘洛尔辅助治疗甲亢患者临床效果显著、可有效改善患者甲状旁腺激素水平及血钙及骨钙素水平,安全性高。
【Objective】To investigate the clinical efficacy of propranolol combined with methimazole in the adjuvant treatment of hyperthyroidism.【Methods】Fifty-six cases of hyperthyroidism patients admitted to the department of endocrine surgery in our hospital from April 2018 to April 2019 were selected as the study objects,and were divided into the control group(n=28 cases)and the observation group(n=28 cases)according to the random number table.Patients in the control group were treated with merthimazole and patients in the observation group were treated with merthimazole plus propranolol.Patients in both groups were treated for 3 months.The total effective rate,serum parathyroid hormone level,changes in bone metabolism and adverse reactions in the two groups were compared.【Results】After 3 months of treatment,the total effective rate of patients in the observation group(92.86%)was higher than that in the control group(71.43%)(P<0.05).After treatment,the serum parathyroid hormone level in the two groups was higher than that before treatment,and the serum parathyroid hormone level in the observation group(24.53±2.33 pg/mL)was significantly higher than that in the control group(19.23±2.01 pg/mL)(P<0.05).After treatment,the bone metabolism indexes(serum calcium and osteocalcin levels)of the patients in the two groups decreased,and the decrease degree of these indexes in the observation group was more significant than that in the control group(P<0.05).The incidence of total adverse reactions(10.71%)in the observation group was lower than that in the control group(35.71%),and the difference was statistically significant(P<0.05).【Conclusion】Propranolol can improve the level of parathyroid hormone and serum calcium and osteocalcin in patients with hyperthyroidism.
作者
厉艳萍
吴瑞敏
张方方
杨秀真
LI Yanping;WU Ruimin;ZHANG Fangfang;YANG Xiuzhen(Department of Endocrinology,Henan Tongxu People's Hospital,Tongxu,Henan 475400,China;Department of Endocrinology,Huaihe Hospital,Henan University,Kaifeng,Henan 475000,China)
出处
《中国医学工程》
2020年第3期43-45,共3页
China Medical Engineering
关键词
普萘洛尔
甲巯咪唑
甲亢
血清甲状旁腺激素
propranolol
methimazole
hyperthyroidism
serum parathyroid hormone
