摘要
目的观察参芪苓碧汤对结直肠癌术后脾虚证患者的临床疗效及其对免疫功能的影响。方法将84例结直肠癌术后脾虚证的患者随机分成参芪苓碧汤治疗组(40例)和对照组(44例)。对照组给予常规西医治疗(包括静脉化疗、营养支持、补液治疗等);参芪苓碧汤治疗组在常规西医治疗的基础上给予参芪苓碧汤。两组治疗4周后,观察治疗前后患者的脾虚证候评分、体力状况(KPS评分)、免疫功能(外周血T淋巴细胞亚群、CD19^+以及CD3^-CD^16/56)等指标的变化情况。结果参芪苓碧汤治疗组、对照组脾虚证候评分下降(P<0.05);组间治疗后对比存在差异,有统计学意义(P<0.05)。治疗组KPS积分较治疗前有显著升高(P<0.05),对照组无统计学意义(P>0.05);治疗后,参芪苓碧汤治疗组CD3^+、CD4^+、CD4^+/CD8^+、CD3-CD16/56^+、CD19^+水平均明显升高(P<0.05),对照组则无统计学意义(P>0.05)。治疗组和对照组CD8^+T细胞水平均下降(P<0.05),组间治疗后对比,CD4^+存在差异,具有统计学意义(P<0.05);结论参芪苓碧汤可改善结直肠癌术后脾虚证患者的脾虚症状,调节机体免疫功能,进而提高患者的生存质量。
Objective To observe the therapeutic effects on spleen deficiency after colorectal cancer operation and the impacts on immune function treated with"Shen Qi Ling Bi Decoction". Methods Eighty-four subjects were randomly divided into two groups: control group in which 44 cases were treated with the conventional treatment including intravenous chemotherapy, fluid infusion and nutrition support,and treatment group in which 40 cases were treated with the conventional treatment and"Shen Qi Ling Bi Decoction". After 4-week treatment,spleen deficiency symptom score,KPS score, the immune immunological indexes(T lymphocyte subsets, CD19^+ and CD3-CD16/56^+) were observed before and after treatment in the patients. Results After 4-week treatments, the scores of spleen deficiency syndrome were reduced significantly in treatment group and control group(P < 0.05).There were great differences between two groups(P < 0.05). Karnofsky performance status was increased significantly in treatment group(P < 0.05),and insignificantly in control group(P>0.05). The counts of CD3^+, CD4^+, CD4^+/CD8^+, CD3-CD16/56^+, CD19^+ were significantly increased in treatment group(P < 0.05), and insignificantly in control group(P > 0.05). The count of CD8+was reduced significantly in treatment group and control group(P < 0.05).There was great difference in CD4+between two groups(P <0.05);Conclusion The Shen Qi Ling Bi Decoction relieves spleen deficiency symptoms,enhances cellular immune function and improves the living quality in the patients.
作者
刘霖
张菁
方捷
周明
黄伟
姜文静
谢东宇
Liu Lin;Zhang Jing;Fang Jie;Zhou Ming;Huang Wei;Jiang Wenjing;Xie Dongyu(Department of Pharmacy,Dahua Hospital ofXuhui District,Shanghai 200237,China;Department of Traditional Chinese Medicine,Dahua Hospital ofXuhui District,Shanghai 200237,China;Department of General Surgery,Dahua Hospital ofXuhui District,Shanghai 200237,China;Department of Spleen-stomach,Zhenjiang Hosptial of Traditional Chinese Medicine,Zhenjiang 212003,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2019年第12期2813-2818,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
上海市卫生和计划生育委员会上海市名老中医学术经验研究项目(SHGZS-2017005):PMS张菁上海市名老中医学术经验研究工作室,负责人:张菁
上海市中医药发展办公室上海市基层名老中医传承研究工作室建设项目(JCZYGZS-008):PMS张菁上海市基层名老中医传承研究工作室,负责人:张菁
上海市徐汇区卫生和计划生育委员会医学高峰学科建设项目(SHXH201711):疝与腹壁外科,负责人:胡强.
关键词
结直肠癌
脾虚证
参芪苓碧汤
免疫功能
Colorectal cancer
spleen deficiency
Shen Qi Ling Bi
immune function
