摘要
目的探讨狼疮抗凝物(lupus anticoagulant,LAC)阳性患者病例的临床特征和实验室检查。方法回顾性分析2017年1月1日至2018年4月25日我院住院患者中所有LAC检查结果阳性患者的病例资料,以LAC标准化比值>1.20判断为阳性,共192例,再将其分为抗磷脂综合征(antiphospholipid syndrome,APS)阳性组28例和APS阴性组(下面简称非APS组)164例,并进行比较。结果 APS阳性组男18例,女10例,年龄(47.71±22.52)岁,非APS组男109例,女55例,年龄(53.56±21.17)岁,两组之间的平均年龄与性别组成之间差异无统计学意义(P>0.05);两组之间血栓事件发生率、抗心磷脂抗体阳性率、抗β2糖蛋白1阳性率的差异有统计学意义(P<0.05)。结论 LAC阳性是血栓发生的危险因素,APS血栓事件以动脉血栓为主,APA联合检测对APS诊断灵敏度高。
Objective To investigate the clinical features and laboratory tests of lupus anticoagulant(LAC)-positive patients. Methods Retrospective analysis of case data of all patients with positive LAC test results in our hospital from January 2017 to April 2018. Statistical analysis and analysis were performed. The normalized ratio of LAC >1.20 was considered as positive, with a total of 192 cases, and then divided into antiphospholipid syndrome(APS) positive group of 28 cases and APS negative group(hereinafter referred to as non-APS group) 164 cases, and for comparison. Results There were 18 males and 10 females with age of(47.71±22.52) in the APS positive group. There were 109 males and 55 females in the non-APS group. The age was(53.56±21.17). There was no difference between the average age and gender composition between the two groups. Statistical significance(P>0.05);the incidence of thrombotic events, anticardiolipin antibody positive rate, and anti-β2 glycoprotein 1 positive rate were statistically significant between the two groups(P<0.05). Conclusion LAC positive is a risk factor for thrombosis. APA combined detection has high sensitivity for APS diagnosis.
作者
刘长鈺
黄锦维
龚彩平
李广华
范小斌
周惠娜
LIU Chang-yu;HUANG Jin-wei;GONG Cai-ping(Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Guangzhou 510000,Guangdong Province,China)
出处
《罕少疾病杂志》
2020年第2期70-72,共3页
Journal of Rare and Uncommon Diseases
关键词
狼疮抗凝物
抗磷脂综合征
抗磷脂抗体
血栓形成
Lupus Anticoagulant(LAC)
Antiphospholipid Syndrome(APS)
Antiphospholipid Antibody(APA)
Thrombosis
