摘要
目的:分析初始小剂量甲巯咪唑治疗对Graves病甲状腺功能亢进症(甲亢)患者甲状腺功能和内脂素(Visfatin)、肿瘤坏死因子-α(Tumor necrosis factor-alpha, TNF-α)、白介素-6(Interleukin-6, IL-6)水平的影响。方法:选择我院2017年1月-2018年6月诊治的125例Graves病甲亢患者,根据入院编号随机数字表法分为两组。对照组63例给予甲硫咪唑15 mg/次,2次/d;研究组62例给予甲硫咪唑10 mg/次,2次/d,两组均连续治疗6个月,对比两组治疗总有效率、治疗前后甲状腺功能和血清Visfatin、TNF-α、IL-6水平的变化。结果:治疗后,研究组的治疗总有效率显著高于对照组(90.32%vs. 77.78%,P<0.05);两组患者的甲状腺功能指标血清游离三碘甲状腺原氨酸(Free triiodothyronine, FT3)、血清游离甲状腺素(FT4)水平均显著降低、敏感促甲状腺激素(Sensitive thyroid stimulating hormone, s TSH)水平均显著升高,且研究组以上指标变化较对照组更显著(P<0.05);两组患者的血清Visfatin、TNF-α、IL-6水平均较治疗前显著下降,且研究组以上指标均显著低于对照组(P<0.05)。结论:初始小剂量(10 mg/次)甲巯咪唑治疗Graves病甲亢的疗效显著优于甲硫咪唑15 mg/次治疗,可能与其有效改善患者的甲状腺功能和血清Visfatin、TNF-α、IL-6等炎症因子水平有关。
Objective: To analyze the clinical efficacy of initial low-dose methimazole in the treatment of patients with Graves’ hyperthyroidism and its effect on the thyroid function and visfatin, TNF-α and IL-6 levels. Methods: 125 patients with Graves’ hyperthyroidism who were diagnosed in our hospital from January 2017 to June 2018 were selected and divided into two groups according to the admission number. 63 cases in the control group were given methimazole 15 mg/time, twice a day. 62 cases in the study group were given methimazole 10 mg/time, twice a day, and both groups were treated continuously for 6 months. The total effective rate, changes of thyroid function and the levels of Visfatin, TNF-α, IL-6 of before and after treatment were compared between two groups. Results: After treatment, the total effective rate of study group was significantly higher than that of the control group(90.32% vs. 77.78%, P<0.05). After treatment, the levels of thyroid function indexes of FT3 and FT4 in the two groups were significantly decreased, while the s TSH level was significantly increased, and the above indicators in the study group improved more significant than the control group(P<0.05). After treatment, the levels of serum Visfatin, TNF-α, and IL-6 decreased in the two groups were significantly lower than those before treatment,and the above indexes of the study group were more significantly lower than the control group(P<0.05). Conclusions: The initial low-dose(10 mg/time) methimazole was significantly better than methimazole 15 mg/treatment in the treatment of Graves’ disease, which may be related to effectively improve the thyroid function of patients and the levels of inflammatory factors such as serum Visfatin, TNF-α,IL-6.
作者
张新
王玲
王世蓉
蒋一凡
马淑红
ZHANG Xin;WANG Ling;WANG Shi-rong;JIANG Yi-fan;MA Shu-hong(Department of Endocrinology,Panjin Liaohe Oilfield Gem Flower Hospital to the Fourth Clinical College affiliated to Jinzhou Medical University,Panjin,Liaoning,124010,China)
出处
《现代生物医学进展》
CAS
2020年第4期764-767,共4页
Progress in Modern Biomedicine
基金
辽宁省科技厅科研计划基金项目(201802705)。
关键词
初始小剂量
甲巯咪唑
GRAVES病甲亢
疗效
炎症因子
Initial low-dose
Methimazole
Graves’ hyperthyroidism
Curative effect
Inflammatory factor
