摘要
目的收集2016~2018年在广州市妇女儿童医疗中心就诊腹泻儿童病例资料,分析轮状病毒(Rotavirus,RV)和肠道腺病毒(Adenovirus,AdV)感染流行的特点。方法采集2016~2018年诊断急性腹泻儿童新鲜粪便样本,用胶体金检测法检测RV和AdV抗原,对结果和临床信息进行分析。结果符合分析要求的样本共6 568例,男性4 098例,女性2 470例。RV感染4 645例,AdV感染1 317例,RV和AdV合并感染606例。RV感染率以12月~次年3月最高,AdV和RV+AdV合并感染率从5月开始明显增高,在9~10月达到峰值。RV感染以1~3岁为主;AdV感染和RV+AdV合并感染以2岁内为优势。发热和呼吸道感染是发生率最高的临床并发症,AdV感染和RV+AdV合并感染较易出现发热症状。结论 RV和AdV是引起广州地区儿童急性腹泻的重要病原体。RV所致腹泻在冬春季高发,时间有明显的地域差异。AdV感染无明显的月份差异。两种病毒感染导致的儿童腹泻多发于学龄前,且AdV在0~1岁年龄段检出率最高。临床可参考腹泻发生特点实施用药治疗。
Objective Data of children with diarrhea treated from 2016~2018 were collected to analyze the epidemic characteristics of Rotavirus(RV) and Adenovirus(AdV) infection. Methods Fresh stool samples from children diagnosed with acute diarrhea from 2016~2018 were collected, RV and AdV antigens were detected by colloidal gold assay, and 6 568 positive results and clinical information were analyzed. Results A total of 6 568 cases including 4 098 males and 2 470 females. There were 4 645 cases of RV infection,1 317 cases of AdV infection and 606 cases of combined infection of RV and AdV infection. RV infection rate was the highest from December to March of the next year, AdV and RV+AdV combined infection rates increased significantly from May and reached the peak in September to October. RV infection was mainly at 1~3 years old children, AdV and RV+AdV co-infection were predominance in 2 years. Fever and respiratory tract infection were the most common clinical complications. AdV infection and RV+AdV co-infection were more likely to cause fever. Conclusion RV and AdV are important pathogens causing acute diarrhea in children in Guangzhou. RV-induced diarrhea is usually high in winter and spring, and AdV infection has no significant monthly difference. Diarrhea caused by the two viruses is morecommon in preschool children, and the detection rate of AdV is the highest between 0~1 year. Clinical characteristic of diarrhea implementation of drug treatment for reference.
作者
梁卓夫
邝璐
姚淑雯
李彩金
何艳明
LIANG Zhuo-fu;KUANG Lu;YAO Shu-wen;LI Cai-jin;HE Yan-ming(Guangzhou Women and Children’s Medical Center,Guangzhou 510120)
出处
《现代检验医学杂志》
CAS
2020年第2期128-131,共4页
Journal of Modern Laboratory Medicine
