摘要
目的:观察阿立哌唑与奧氮平在精神分裂症治疗过程中对患者认知功能的影响,旨在为临床用药提供借鉴依据。方法:将本院收治的60例精神分裂症患者列为研究对象,随机分为治疗1组及治疗2组,分别给予阿立哌唑及奥氮平口服;在治疗前、后使用阳性和阴性症状量表(PANSS)、威斯康星卡片分类测验(WCST)、韦氏数字广度测验(DS)、爱荷华赌博任务(IGT)及情感强度识别任务(EIRT)评定两组病情及认知功能。结果:治疗前两组PANSS总分及各项评分比较,差异无统计学意义(P>0.05),治疗后PANSS总分及各项评分明显下降(P<0.05);两组治疗后PANSS各项评分及总分比较,差异无统计学意义(P>0.05);两组治疗后DS、WCST、IGT评分明显提高(P<0.05);治疗2组治疗后DS评分高于治疗1组(P<0.05),两组治疗后WCST、IGT评分比较,差异无统计学意义(P>0.05);治疗1组治疗后快乐、恐惧、愤怒、厌恶识别四项评分明显提高(P<0.05);治疗2组治疗后快乐、悲伤识别较治疗前明显提高(P<0.05);两组治疗前后各项评分比较,差异均无统计学意义(P>0.05)。结论:奥氮平与阿立哌唑对精神分裂症患者临床症状及部分认知功能均具有改善作用,阿立哌唑对此类患者工作、记忆方面具有更好的改善作用。
Objective:To observe the effect of aripiprazole and olanzapine on the cognitive function in patients with schizophrenia in order to provide a reference evidence for the clinical medication.Methods:A total of 60 patients with schizophrenia who were admitted in our hospital were included in the study and randomized into the treatment group 1 and treatment group 2.The patients in the two groups were given aripiprazole and olanzapine,respectively.PANSS,WCST,DS,IGT,and EIRT were used to evaluate the disease condition and cognitive function before and after treatment in the two groups.Results:Comparison of PANSS scores and other various scores before treatment between the two groups was not significantly different(P>0.05);however,PANSS scores and other various scores after treatment were significantly reduced(P<0.05).Comparison of PANSS scores and other various scores after treatment between the two groups was not significantly different(P>0.05).DS,WCST,and IGT scores before treatment between the two groups was comparable(P>0.05),and those scores after treatment were significantly elevated(P<0.05).DS score after treatment in the treatment 2 group was significantly higher than that in the treatment 1 group(P<0.05).Comparison of WCST and IGT scores after treatment between the two groups was not significantly different(P>0.05).The four cognition scores of happiness,fear,anger,and disgust after treatment in the treatment 1 group were significantly elevated(P<0.05),while the cognition of happiness and sadness after treatment in the treatment 2 group was significantly elevated when compared with before treatment(P<0.05).The comparison of various scores before and after treatment between the two groups was not significantly different(P>0.05).Conclusion:s Aripiprazole and olanzapine can improve the clinical symptoms and partial cognitive function in patients with schizophrenia,while aripiprazole can make a better effect on the work and memory.
作者
王小红
WANG Xiao-hong(Shalingzi Hospital of Zhangjiakou City, Zhangjiakou,075100,China)
出处
《海南医学院学报》
CAS
2020年第9期673-676,共4页
Journal of Hainan Medical University
基金
河北省科学技术研究发展计划项目(1221068D)。
关键词
精神分裂症
阿立哌唑
奥氮平
认知功能
Schizophrenia
Aripiprazole
Olanzapine
Cognitive function
