摘要
目的:初步探讨不同临床分型新型冠状病毒肺炎(COVID-19)患者心肌损伤标志物特征。方法:本研究是一项回顾性单中心研究,纳入了2020年1月至2020年2月,共122例COVID-19确诊病例,其中轻型/普通型共92例,重型/危重型共30例。通过实时RT-PCR确诊病例,并收集流行病学,人口统计学,临床分析,放射学特征和实验室数据。结果:根据患者病情临床分型,将所有COVID-19患者分为两组,一组为轻型和普通型,另一组为重型/危重型患者。比较两组患者一般情况结果显示:重症/危重型COVID-19患者年龄、WBC、中性粒细胞百分比、血清淀粉样蛋白A、尿素氮、谷草转氨酶、心率、体温、呼吸次数、死亡率和肺部病变范围均高于轻型/普通型患者,而淋巴细胞数、淋巴细胞百分比和血氧饱和度则低于轻型/普通型患者(P<0.05)。比较不同病情分型COVID-19患者心肌损伤标志物水平和急性心肌受损的比例结果提示:重型/危重型患者心肌酶指标、心肌酶升高所占比例和hs-cTnI水平均高于轻型/普通型患者,急性心肌受损的比例(11.1%vs.42.3%)也明显升高(P<0.05)。结论:重症COVID-19患者发生急性心肌损伤的比例为42.3%;重症COVID-19患者心肌酶、hs-cTnI水平高于轻症患者。
Objective:To investigate the markers of myocardial injury in patients with different clinical types of novel coronavirus pneumonia.Methods:This study is a retrospective single-center study,a total of 122 new coronavirus pneumonia cases were included from January 2020 to February 2020,including 92 cases of light/normal type and 30 cases of heavy/critical type.Cases were confirmed by real-time RT-PCR and epidemiological,demographic,clinical analysis,as well as radiological characteristics and laboratory data were collected.Results:According to the clinical classification of the patients,all the patients with new coronavirus pneumonia were divided into two groups,one group was mild and normal type,the other group was severe/critical type.Compare two groups of patients in general,the result show that the severe type/critical new coronavirus pneumonia patients age,WBC,neutrophil percentage,serum amyloid A,urea nitrogen,AST,heart rate,body temperature,breathing rate,death rate and lung lesions were higher than light/normal patients,lymphocyte count,percentage of lymphocytes and blood oxygen saturation is below the light/normal patients(P<0.05).To compare different disease classification new coronavirus pneumonia in patients with myocardial injury markers level and the proportion of acute myocardial damage.Results:suggest heavy/critically ill patients with myocardial enzyme index,proportion of elevated myocardial enzymes and cTnI levels are higher than light/normal patients,the proportion of acute myocardial damage(11.1%vs.42.3%)also increased significantly(P<0.05).Conclusions:The incidence of acute myocardial injury in patients with severe new coronavirus pneumonia was 42.3%.The levels of cardiac enzymes and cTnI in patients with severe new coronavirus pneumonia were higher than those in patients with mild cases.
作者
郭宁
黄素兰
胡鑫
葛良清
梁莉
罗艳兰
GUO Ning;HUANG Sulan;HU Xin;GE Liangqing;LIANG Li;LUO Yanlan(Department of Cardiology,First People’s Hospital of Changde,Changde 415000,China)
出处
《心肺血管病杂志》
2020年第4期366-369,共4页
Journal of Cardiovascular and Pulmonary Diseases
基金
湖南省卫生健康委科研计划项目资助(2020224)。
关键词
新型冠状病毒肺炎
心肌损伤标志物
初步探讨
2019 novel coronavirus pneumonia
Markers of myocardial injury
Preliminary study
